嗜酸性粒细胞性胃肠炎42例临床分析
[Abstract]:Objective: to retrospectively analyze the clinical characteristics and therapeutic effects of EGE (Eosinophilic gastroenteritis, eosinophilic gastroenteritis in the second affiliated Hospital of Dalian Medical University in recent 10 years. Further understanding of EGEprovides a theoretical basis for more effective clinical diagnosis and treatment of EGE. Methods: a total of 42 inpatients diagnosed as EGE from January 2006 to November 2016 were searched by the Medical record Retrieval system of the second affiliated Hospital of Dalian Medical University. Physical and chemical examination, endoscopy and pathological biopsy, time from onset to diagnosis, treatment and recurrence. Using SPSS22.0 software, K-W H nonparametric rank sum test was used to test the difference of eosinophil level in EGE subtypes, and R 脳 C linked table chi-square test was used to compare the positive rate of different parts of gastroenteroscopy. Multiple independent sample rank sum tests were performed on the difference of treatment methods and efficacy. Results in 42 patients with EGE, the ratio of male to female was 1: 1.8, the average age was 46.21 卤15.74 years, and the age distribution was 40-50 years old. There were 24 cases with history of allergy, 10 cases with anaphylaxis, 37 cases with mucosal type (88%), 2 cases with myometrium type, 5 cases with serosal type, 3 cases with serosal type, 24 cases with anaphylaxis history, 10 cases with chronic allergic disease, 37 cases with mucosal type (88%), 2 cases with muscular layer type (5 cases) and 3 cases with serosal type. The clinical symptoms were abdominal pain (38 cases, 90.4%), followed by diarrhea (15 cases, 35.70.3.The absolute value of eosinophilic cells in 36 cases of all patients) was increased, accounting for 85.7% AECs: (0.18-4.5) 脳 109% L, mean (1.81 卤1.13) 脳 10 9 / L (mean: 1.81 卤1.13) 脳 109% 路L ~ (-1) 路min ~ (-1) 路L ~ (-1) ~ (-1) 脳 10 ~ (9) 路L ~ (-1) 路L ~ (-1) ~ (-1) 脳 10 ~ (9) 路L ~ (-1) 路L ~ (-1). In different subtypes, the mean AECs of mucosal type was (1.51 卤0.8) 脳 10 9 / L, that of muscular layer was (3.6 卤0.3) 脳 10 9 / L, and that of serosal type was (4.35 卤0.14) 脳 10 9 / L. The level of AECs in serous type patients was higher than that in mucosal type patients with H mucosal type and serosal type (0.0080.05 / 3), the difference was statistically significant. 4. Comparison of positive rate of biopsy in different parts of gastroenteroscopy: gastroscopy: duodenal positive rate gastric antral positive rate gastric body positive rate: gastroscope: duodenal positive rate gastric antral positive rate gastric body positive rate The rate of 蠂 2 was 8.93% (P < 0.05) and the difference was statistically significant (P < 0.05). Colonoscopy: ileal terminal positive rate ileocecal positive rate rectal positive rate descending colonic positive rate, 蠂 2 intestinal mucosa 17.62PU 0.0005270.05.5The three treatment methods and curative effect are different. Simple hormone therapy and combined hormone therapy were better than simple symptomatic therapy, and the difference was statistically significant (H simple to symptom-simple hormone -2.70% P0. 0070.05 / 3 0.0167% H simple-combined hormone-2.59% -0.010.05 / 3 / 0.0167). There was no difference between single hormone therapy and combined hormone therapy (H simple hormone combined with hormone 0.46790.05 / 30.0167) .6.The myometrium type patients were more likely to recur than other subtypes, and the patients with simple symptomatic therapy were more prone to relapse than other treatment groups. Conclusion among the patients with the history of food, drug allergy and allergic diseases, the mucosal type is the most common in the patients with age. The abdominal pain is the most common symptom in the patients with EGE, and the most common symptom is colic. The higher AECs level in blood was the diagnostic clue for EGE, and the AECs level in serous type was higher than that in mucosal type .EGE could be diagnosed by gastroenteroscopy and biopsy, but the positive rate of biopsy was different in different parts. Among them, duodenum and ileum were the highest. The curative effect of single hormone therapy and combined hormone therapy was better than that of simple symptomatic therapy.
【学位授予单位】:大连医科大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:R57
【参考文献】
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