中药保留灌肠加口服美沙拉嗪肠溶片对溃疡性结肠炎患者血小板状态的影响

发布时间：2018-08-05 18:14

【摘要】：目的探讨中药保留灌肠加口服美沙拉嗪肠溶片对溃疡性结肠炎(UC)患者血小板功能的影响。方法选择2013年1月至2014年6月在该院肛肠科接受治疗的60例UC患者。根据数字法随机分成观察组及对照组各30例。观察组给予中药保留灌肠及美沙拉嗪肠溶片联合治疗,对照组单纯给予美沙拉嗪肠溶片治疗,8 w后对患者进行复查,对比两组疗效以及两组治疗前后的C反应蛋白(CRP)、血沉及血小板计数。结果观察组的总有效率显著高于对照组(P0.05)。两组治疗前的CRP、血沉、血小板计数相比无统计学差异(P0.05)。治疗8 w后,观察组的CRP、血沉及血小板计数均显著低于对照组(均P0.05)。结论中药保留灌肠加口服美沙拉嗪肠溶片治疗UC可较好地改善患者症状,增大疗效,改善其血小板功能,值得推荐。
[Abstract]:Objective to investigate the effect of retention enema and oral mesalazine enteric-coated tablets on platelet function in patients with ulcerative colitis (UC). Methods 60 patients with UC were selected from January 2013 to June 2014. According to the digital method, 30 cases in the observation group and 30 cases in the control group were randomly divided into two groups. The observation group was treated with traditional Chinese medicine retention enema and mesalazine enteric-coated tablets, while the control group was treated with mesalazine enteric-coated tablets for 8 weeks. The efficacy of the two groups and the erythrocyte sedimentation rate (ESR) and platelet count of C reactive protein (CRP),) before and after treatment were compared. Results the total effective rate of the observation group was significantly higher than that of the control group (P0.05). There was no significant difference in CRP, ESR and platelet count between the two groups before treatment (P0.05). After 8 weeks of treatment, CRP, ESR and platelet count in the observation group were significantly lower than those in the control group (P0.05). Conclusion retention enema combined with oral mesalazine enteric-coated tablets can improve the symptoms, increase the curative effect and improve the platelet function of UC patients, which is worthy of recommendation.
【作者单位】：承德医学院附属医院肛肠科;承德市双滦区人民医院;
【基金】：承德市科技支撑计划项目(No.20130263)
【分类号】：R574.62

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