肝硬化食管胃静脉曲张早期再出血危险因素分析
发布时间：2018-08-08 16:46
【摘要】：目的通过对310例肝硬化食管胃静脉曲张出血并行内镜治疗患者进行临床病例回顾性分析，初步探寻经Qg镜治疗后早期再出血危险因素，为临床工作提供一定的参考。 方法回顾性分析宁夏医科大学总医院2009年1月至2012年12月收治的伴有食管胃静脉曲张破裂出血行内镜下治疗的肝硬化患者的临床资料，，按6周内是否发生再出血分为再出血组和对照组,应用SPSS17.0统计软件分析,将差异有显著性的指标运用二元非条件Logistic回归模型进行分析。分析各因素对早期再出血的影响,进一步找出独立的危险因素。P值小于0.05，认为差异有统计学意义。 结果分析310例患者中，34例(10.9%)发生再出血,276例未再出血患者为对照组。两组在Na+、ALB、PTA、INR、门静脉内径、脾脏厚度、腹水程度、Child-Pugh分级、静脉曲张程度的差异有统计学意义。对上述观察指标进行二元非条件Logistic回归分析，肝功能Child-Pugh分级、血清Na+、血浆白蛋白ALB、脾脏厚度、中-大量腹水、重度静脉曲张是早期再出血的独立危险因素。 结论1、肝功能Child-Pugh分级、血清Na+、血浆白蛋白ALB、脾脏厚度、中-大量腹水、重度静脉曲张是早期再出血的独立危险因素。 2、肝功能Child-Pugh分级为C级，且大量腹水的EGVB患者更易发生早期再出血。
[Abstract]:Objective to explore the risk factors of early rebleeding after QG therapy in 310 patients with esophageal and gastric variceal bleeding combined with endoscopic therapy in order to provide some reference for clinical work. Methods the clinical data of patients with esophageal and gastric variceal bleeding treated by endoscope in Ningxia Medical University General Hospital from January 2009 to December 2012 were analyzed retrospectively. According to whether rebleeding occurred within 6 weeks, the patients were divided into two groups: rebleeding group and control group. The statistical software SPSS17.0 was used to analyze the significant difference between the two groups, and the binary non-conditional Logistic regression model was used to analyze the difference. The influence of various factors on early rebleeding was analyzed and the independent risk factor. P value was found to be less than 0. 05. The difference was statistically significant. Results 34 cases (10.9%) of 310 patients with recurrent hemorrhage were analyzed as control group. There were significant differences in the diameter of portal vein, the thickness of spleen, the degree of ascites and Child-Pugh grade and the degree of varicose vein between the two groups. The risk factors of early rebleeding were analyzed by binary non-conditional Logistic regression analysis, liver function Child-Pugh grade, serum Na, plasma albumin, spleen thickness, moderate to massive ascites and severe varicose veins. Conclusion 1. Child-Pugh grade of liver function, serum Na, plasma albumin, thickness of spleen, medium to large ascites, severe varicose veins are independent risk factors for early rebleeding. 2. Child-Pugh grade of liver function is C grade. EGVB patients with a large amount of ascites are more prone to early rebleeding.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R575.2
本文编号：2172403
[Abstract]:Objective to explore the risk factors of early rebleeding after QG therapy in 310 patients with esophageal and gastric variceal bleeding combined with endoscopic therapy in order to provide some reference for clinical work. Methods the clinical data of patients with esophageal and gastric variceal bleeding treated by endoscope in Ningxia Medical University General Hospital from January 2009 to December 2012 were analyzed retrospectively. According to whether rebleeding occurred within 6 weeks, the patients were divided into two groups: rebleeding group and control group. The statistical software SPSS17.0 was used to analyze the significant difference between the two groups, and the binary non-conditional Logistic regression model was used to analyze the difference. The influence of various factors on early rebleeding was analyzed and the independent risk factor. P value was found to be less than 0. 05. The difference was statistically significant. Results 34 cases (10.9%) of 310 patients with recurrent hemorrhage were analyzed as control group. There were significant differences in the diameter of portal vein, the thickness of spleen, the degree of ascites and Child-Pugh grade and the degree of varicose vein between the two groups. The risk factors of early rebleeding were analyzed by binary non-conditional Logistic regression analysis, liver function Child-Pugh grade, serum Na, plasma albumin, spleen thickness, moderate to massive ascites and severe varicose veins. Conclusion 1. Child-Pugh grade of liver function, serum Na, plasma albumin, thickness of spleen, medium to large ascites, severe varicose veins are independent risk factors for early rebleeding. 2. Child-Pugh grade of liver function is C grade. EGVB patients with a large amount of ascites are more prone to early rebleeding.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R575.2
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