配对血浆滤过吸附联合高容量血液滤过治疗老年重症胰腺炎的疗效及对炎症因子的影响
发布时间:2018-08-09 11:59
【摘要】:目的探讨配对血浆滤过吸附(CPFA)联合高容量血液滤过(HVHF)治疗老年急性重症胰腺炎(SAP)的疗效及其对炎症因子的影响。方法选择该院2012年1月至2014年1月收治的60例老年SAP患者,按随机数字表法平均分为两组各30例,研究组给予CPFA联合HVHF治疗,对照组仅给予HVHF治疗,比较两组患者治疗前和治疗7 d后急性生理及慢性健康状况(APACHE)Ⅱ评分及平均动脉压(MAP)、心率(HR)、血氧饱和度(Sp O2)等指标变化、血浆白细胞介素(IL)-6、IL-8、IL-10、肿瘤坏死因子(TNF)-α及C反应蛋白(CRP)、白细胞计数(WBC)等水平以及住院时间和治疗过程中不良反应情况。结果研究组治疗7 d后APACHEⅡ评分较治疗前明显降低,且低于对照组(P0.05);研究组治疗后MAP、HR及Sp O2水平较治疗前明显改善,且改善程度明显优于对照组(均P0.05);研究组治疗后血浆IL-6、IL-8、IL-10、TNF-α、CPR及WBC水平较治疗前明显改善,且改善程度均明显优于对照组(均P0.05);研究组住院时间短于对照组(P0.05);两组患者治疗过程中均未出现凝血、膜过敏、栓塞及血小板减少等不良反应。结论 CPFA联合HVHF治疗SPA疗效显著,可有效改善患者炎症因子水平,缩短住院时间,安全可靠,值得临床推广应用。
[Abstract]:Objective to investigate the effect of paired plasma filtration adsorption (CPFA) combined with high volume hemofiltration (HVHF) on elderly patients with severe acute pancreatitis (SAP) and its effect on inflammatory factors. Methods from January 2012 to January 2014, 60 elderly patients with SAP were randomly divided into two groups: 30 cases in each group. The study group was treated with CPFA combined with HVHF, while the control group was treated with HVHF only. The changes of (APACHE) 鈪,
本文编号:2174007
[Abstract]:Objective to investigate the effect of paired plasma filtration adsorption (CPFA) combined with high volume hemofiltration (HVHF) on elderly patients with severe acute pancreatitis (SAP) and its effect on inflammatory factors. Methods from January 2012 to January 2014, 60 elderly patients with SAP were randomly divided into two groups: 30 cases in each group. The study group was treated with CPFA combined with HVHF, while the control group was treated with HVHF only. The changes of (APACHE) 鈪,
本文编号:2174007
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