腹水钙卫蛋白含量对肝硬化自发性细菌性腹膜炎的诊断评价
发布时间：2018-08-24 08:47
【摘要】：目的探讨肝硬化腹水中钙卫蛋白水平对自发性细菌性腹膜炎(SBP)的诊断价值。方法从108例肝硬化腹水患者获得136份腹水标本,分成试验组(SBP)41份和对照组(非SBP)95份,检测腹水中钙卫蛋白含量,同时两组均收集临床资料及腹水相关检测结果,比较使用抗菌药物前试验组和对照组腹水钙卫蛋白含量水平,以及试验组使用抗菌药物前后腹水钙卫蛋白含量变化,绘制ROC曲线,确定腹水钙卫蛋白诊断SBP的临界值。结果治疗前试验组钙卫蛋白含量270~15 273ng/ml,显著高于对照组0~75ng/ml(P0.001),试验组治疗后钙卫蛋白含量9~13 043ng/ml,显著低于治疗前,差异有统计学意义(P0.01),钙卫蛋白与中性粒细胞(PMN)呈相关性(r=0.76039,P0.0001);以687ng/ml作为诊断的临界值,此时钙卫蛋白诊断SBP的敏感性90.7%、特异性为86.3%。结论腹水中钙卫蛋白水平可以作为诊断SBP的特异性和敏感性较好的指标,值得临床推广。
[Abstract]:Objective to investigate the diagnostic value of calmodulin level in ascites of liver cirrhosis for spontaneous bacterial peritonitis (SBP). Methods one hundred and thirty-six ascites samples were collected from 108 patients with ascites of liver cirrhosis. They were divided into two groups: (SBP) group (n = 41) and control group (n = 95). The contents of Ca 2 + in ascites were measured. The clinical data and ascites related test results were collected in both groups. The levels of calcitonin in ascites of experimental group and control group were compared before and after the use of antimicrobial agents, and the changes of ascitic fluid calcitonin content in test group before and after the use of antimicrobial agents were compared. The ROC curve was plotted to determine the critical value of ascitic fluid calcitonin in diagnosis of SBP. Results before treatment, the calcitonin content in the trial group was significantly higher than that in the control group (P0.001), and that in the trial group was 9 ~ 13043 ng / ml, significantly lower than that in the control group before and after treatment, and the level of calcitonin in the experimental group was significantly lower than that in the control group (P0. 001). The difference was statistically significant (P0.01). There was a correlation between calcitonin and neutrophil (PMN) (r = 0.76039, P 0.0001), and when 687ng/ml was used as a critical value for diagnosis, the sensitivity and specificity of 687ng/ml in the diagnosis of SBP were 90.7 and 86.3 respectively. Conclusion the level of calmodulin in ascites can be used as a specific and sensitive index for the diagnosis of SBP, and it is worthy of clinical application.
【作者单位】： 湖北省新华医院消化科;华中科技大学附属同济医院感染科;
【基金】：湖北省自然科学基金资助项目(2011CDC104)
【分类号】：R575.2
[Abstract]:Objective to investigate the diagnostic value of calmodulin level in ascites of liver cirrhosis for spontaneous bacterial peritonitis (SBP). Methods one hundred and thirty-six ascites samples were collected from 108 patients with ascites of liver cirrhosis. They were divided into two groups: (SBP) group (n = 41) and control group (n = 95). The contents of Ca 2 + in ascites were measured. The clinical data and ascites related test results were collected in both groups. The levels of calcitonin in ascites of experimental group and control group were compared before and after the use of antimicrobial agents, and the changes of ascitic fluid calcitonin content in test group before and after the use of antimicrobial agents were compared. The ROC curve was plotted to determine the critical value of ascitic fluid calcitonin in diagnosis of SBP. Results before treatment, the calcitonin content in the trial group was significantly higher than that in the control group (P0.001), and that in the trial group was 9 ~ 13043 ng / ml, significantly lower than that in the control group before and after treatment, and the level of calcitonin in the experimental group was significantly lower than that in the control group (P0. 001). The difference was statistically significant (P0.01). There was a correlation between calcitonin and neutrophil (PMN) (r = 0.76039, P 0.0001), and when 687ng/ml was used as a critical value for diagnosis, the sensitivity and specificity of 687ng/ml in the diagnosis of SBP were 90.7 and 86.3 respectively. Conclusion the level of calmodulin in ascites can be used as a specific and sensitive index for the diagnosis of SBP, and it is worthy of clinical application.
【作者单位】： 湖北省新华医院消化科;华中科技大学附属同济医院感染科;
【基金】：湖北省自然科学基金资助项目(2011CDC104)
【分类号】：R575.2
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