多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝的疗效

发布时间：2018-08-26 16:03

【摘要】：目的探讨多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝的疗效及对血脂水平的影响。方法将96例非酒精性脂肪肝患者按照入院顺序随机分成观察组和对照组,每组48例。对照组患者单纯使用多烯磷脂酰胆碱胶囊治疗,口服,456 mg/次,3次/d。观察组在对照组的基础上加用盐酸二甲双胍片口服,500 mg/次,3次/d。两组患者均连续治疗3个月,并在此期间不用其他辅助药物。分别观察并比较两组患者治疗前后的天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、胰岛素抵抗指数(IRI)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)的变化。在治疗过程中分别记录两组患者的不良反应发生情况,并在治疗结束后做出疗效判定。结果观察组和对照组患者的总有效率分别为89.58%和72.92%,观察组总有效率明显高于对照组(P0.05)。观察组患者的ST、ALT、IRI、TC、TG、LDL-C在治疗后均明显下降,HDL-C在治疗后明显上升,各项指标变化差异均具有统计学意义(均P0.05)。对照组患者中仅ST、ALT、TC、TG水平在治疗后下降(P0.05),而IRI、HDL-C、LDL-C在治疗前后差异无统计学意义(P0.05)。此外观察组和对照组的不良反应发生率分别为6.25%和4.17%(P0.05)。结论使用多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝能明显提高疗效,改善肝功能,降低血脂水平和胰岛素抵抗。
[Abstract]:Objective to investigate the effect of polyene phosphatidylcholine combined with metformin in the treatment of non-alcoholic fatty liver. Methods 96 patients with nonalcoholic fatty liver were randomly divided into observation group and control group. The patients in the control group were treated with polyenylphosphatidylcholine capsule only, and the patients were treated by oral administration of 456th mg/ 3 / d. In the observation group, metformin hydrochloride tablets were added to the control group for three times a day. Patients in both groups were treated for 3 months without other adjuvant drugs. The changes of aspartate aminotransferase (AST), alanine aminotransferase (ALT), insulin resistance index (IRI), low density lipoprotein cholesterol (LDL-C) triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) were observed and compared before and after treatment. In the course of treatment, the adverse reactions of the two groups were recorded, and the curative effect was determined after the treatment. Results the total effective rates of observation group and control group were 89.58% and 72.92%, respectively. The total effective rate of observation group was significantly higher than that of control group (P0.05). The ST,ALT,IRI,TC,TG,LDL-C of the patients in the observation group decreased significantly after treatment and HDL-C increased significantly after treatment, and the changes of each index were statistically significant (P0.05). In the control group, only the level of ST,ALT,TC,TG decreased after treatment (P0.05), while the difference of IRI,HDL-C,LDL-C before and after treatment was not statistically significant (P0.05). In addition, the incidence of adverse reactions in the observation group and the control group was 6.25% and 4.17% respectively (P0.05). Conclusion Polyene phosphatidylcholine combined with metformin in the treatment of non-alcoholic fatty liver can significantly improve the efficacy, improve liver function, reduce blood lipid levels and insulin resistance.
【作者单位】：武警江苏总队南京分院内科;
【分类号】：R575.5

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