半夏泻心汤加味辅助吸入抗胆碱气雾剂治疗胃食管反流相关性支气管哮喘

发布时间：2018-08-29 20:12

【摘要】：目的:观察自拟半夏泻心汤加味辅助吸入抗胆碱气雾剂治疗胃食管反流相关性支气管哮喘的疗效。方法:选取2013年5月—2015年5月三亚市中医院收治的经确诊为胃食管反流相关性支气管哮喘患者82例,随机分为观察组和对照组,各41例。对照组患者给予抗胆碱气雾剂常规对症治疗,观察组患者在对照组患者治疗的基础上接受自拟半夏泻心汤加味治疗。比较治疗前后两组患者胃食管反流症状评分、支气管哮喘控制评分、肺功能、以及中医证候疗效。结果:治疗后,观察组患者胃食管反流症状评分与治疗前比较显著下降(P0.01);观察组患者胃食管反流症状评分显著低于同期对照组(P0.01);两组患者支气管哮喘控制评分均较治疗前改善(P0.01),观察组患者较同期对照组改善更加显著(P0.01);两组患者的第1秒用力呼气容积占预计值百分比(FEV1%)和最大呼气流速占预计值百分比(PEV%)均较治疗前显著上升(P0.01),观察组患者较同期对照组上升更加显著(P0.01)。治疗8周后,观察组中医证候疗效明显优于对照组(P0.05)。结论:半夏泻心汤加味辅助吸入抗胆碱气雾剂治疗胃食管反流相关性支气管哮喘患者的临床疗效显著,能有效改善患者胃食管反流症状,有效控制哮喘,改善患者肺功能。
[Abstract]:Objective: to observe the therapeutic effect of Banxia Xiexin decoction (Banxia Xiexin decoction) on gastroesophageal reflux associated bronchial asthma (GERB). Methods: from May 2013 to May 2015, 82 patients with gastroesophageal reflux associated bronchial asthma admitted in Sanya Hospital were randomly divided into observation group and control group, 41 cases in each group. The patients in the control group were treated with anticholine aerosol and the patients in the observation group were treated with Banxia Xiexin decoction on the basis of the treatment of the control group. To compare the scores of gastroesophageal reflux symptom, bronchial asthma control score, pulmonary function and TCM syndromes before and after treatment. Results: after treatment, The scores of gastroesophageal reflux symptoms in the observation group were significantly lower than those in the control group (P0.01), and the scores of bronchial asthma control were improved in both groups (P0.01), and the scores of gastroesophageal reflux symptoms in the observation group were significantly lower than those in the control group (P0.01). The percentage of forced expiratory volume (FEV1%) and maximum expiratory flow rate (PEV%) in both groups were significantly higher than those in the control group (P0.01), and those in the observation group were significantly higher than those before treatment (P0.01), and the percentage of forced expiratory volume (FEV1%) and maximum expiratory flow rate (PEV%) in both groups were significantly higher than those before treatment (P0.01). Compared with the control group, the increase was more significant (P0.01). After 8 weeks of treatment, the therapeutic effect of TCM syndrome in the observation group was significantly better than that in the control group (P0.05). Conclusion: Banxia Xiexin decoction can effectively improve the symptoms of gastroesophageal reflux, control asthma and improve the pulmonary function of patients with gastroesophageal reflux associated bronchial asthma.
【作者单位】：三亚市中医院;解放军总医院海南分院;
【基金】：海南省卫生厅课题项目(琼卫2012LX-29)
【分类号】：R571

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