CRP、PCT、IL-6对评价肝硬化伴全身炎性反应综合征预后的意义

发布时间：2018-09-02 07:06

【摘要】：目的了解肝硬化伴全身炎性反应综合征(SIRS)患者C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素6(IL-6)水平,探讨各指标预测预后的能力。方法收集肝硬化伴SIRS患者56例,依预后分为好转组39例,死亡组17例,出现SIRS后第1、3、7天检测CRP、PCT、IL-6水平,观察CRP、PCT、IL-6与预后的关系。结果第1天两组比较CRP、PCT、IL-6差异均无统计学意义(P0.05);第3天两组相比较PCT、IL-6差异无统计学意义(P0.05),好转组CRP明显下降(P0.05);第7天两组CRP、PCT、IL-6比较,好转组均明显低于死亡组(P0.05)。同组相比,死亡组CRP、PCT、IL-6第1天、第3天、第7天检测值差异无统计学意义(P0.05);好转组PCT、IL-6第3天与第1天相比差异无统计学意义(P0.05),CRP第3天、第7天明显下降(P0.05),好转组PCT、IL-6第7天与第1天相比显著下降(P0.05)。结论 CRP、PCT、IL-6的持续高水平提示预后不良;与PCT、IL-6相比,CRP更能迅速反应病情改善。
[Abstract]:Objective To investigate the levels of C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) in patients with cirrhosis complicated with systemic inflammatory response syndrome (SIRS), and to explore the ability of predicting prognosis of these indexes. Results There was no significant difference in CRP, PCT and IL-6 between the two groups on the first day (P 0.05); there was no significant difference in PCT and IL-6 between the two groups on the third day (P 0.05); CRP in the improvement group decreased significantly (P 0.05); on the seventh day, CRP, PCT and IL-6 in the improvement group were significantly lower than those in the death group (P 0.05). There was no significant difference in the values of CRP, PCT, IL-6 on the first day, the third day and the seventh day (P 0.05). There was no significant difference in the levels of PCT, IL-6 on the third day and the first day (P 0.05). CRP on the third day and the seventh day decreased significantly (P 0.05). PCT, IL-6 on the seventh day in the improvement group decreased significantly compared with the first day (P 0.05). Well, compared with PCT and IL-6, CRP can react more quickly to improve the condition.
【作者单位】：广东省深圳市龙岗中心医院感染科;
【基金】：广东省医学科研基金资助项目(A2013624)
【分类号】：R575.2

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