非酒精性脂肪性肝病合并早发冠心病患者视黄醇结合蛋白4的检测及其意义

发布时间：2018-09-11 06:13

【摘要】：目的:观察非酒精性脂肪性肝病(NAFLD)患者血清视黄醇结合蛋白4(RBP4)水平与早发冠心病的相关性。方法:选择79例NAFLD患者,经冠状动脉造影分为早发冠心病组49例和对照组30例。患者再根据肝脏B超检查结果分为轻、中、重度脂肪肝组。所有患者均抽外周静脉血检测生化指标、RBP4和超敏C反应蛋白(hs-CRP)水平,并行组间比较。结果:与对照组比较,早发冠心病组血清RBP4、hs-CRP、LDL-C水平均明显增加,差异有统计学意义(P0.05)。与轻度脂肪肝组比较,重度脂肪肝组合并冠心病人数增加,中度和重度脂肪肝组RBP4水平增加,差异有统计学意义(P0.05)。结论:对NAFLD患者,RBP4在合并早发冠心病者中增高,并与脂肪肝的严重程度相关。
[Abstract]:Aim: to investigate the relationship between serum retinol binding protein 4 (RBP4) level and premature coronary heart disease (CHD) in (NAFLD) patients with non alcoholic fatty liver disease. Methods: 79 patients with NAFLD were divided into early coronary artery disease group (49 cases) and control group (30 cases). The patients were divided into mild, moderate and severe fatty liver groups according to the results of liver B ultrasound examination. Peripheral venous blood was taken from all patients to detect the levels of RBP4 and hs-CRP. Results: compared with the control group, the serum RBP4,hs-CRP,LDL-C levels in early CHD group were significantly increased (P0.05). Compared with mild fatty liver group, the number of patients with severe fatty liver combined with coronary heart disease increased, the level of RBP4 in moderate and severe fatty liver group increased, the difference was statistically significant (P0.05). Conclusion: the level of RBP4 in patients with NAFLD is higher than that in patients with premature coronary heart disease, and it is related to the severity of fatty liver.
【作者单位】：东南大学附属第二医院心内科;东南大学附属中大医院心内科;
【基金】：南京市医学科技发展项目(YKK11062)
【分类号】：R575.5;R541.4

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