难治性炎症性肠病患者艰难梭状芽胞杆菌感染流行病学及临床特征

发布时间：2018-09-14 14:28

【摘要】：目的探讨难治性炎症性肠病患者艰难梭状芽胞杆菌感染的流行病学及临床特征,为临床防治艰难梭状杆菌感染提供依据。方法选取2013年1月-2016年1月医院收治的难治性炎症性肠病患者92例,采用荧光酶免疫法检测其粪便中艰难梭状芽胞杆菌感染情况,分析艰难梭状芽胞杆菌感染的难治性炎症性肠病患者的临床特征。结果 19例难治性炎症性肠病患者感染艰难梭状芽胞杆菌,感染率为20.65%,其中溃疡性结肠炎患者感染率为20.83%,克罗恩病患者感染率为20.45%;使用抗菌药物、万古霉素和处于活动期的难治性炎症性肠病患者艰难梭状芽胞杆菌感染率显著增高(P0.05);溃疡性结肠炎患者病情严重度为重度、中度和轻度的患者艰难梭状芽胞杆菌感染率分别为44.44%、5.56%和8.33%,差异有统计学意义(P0.05);结肠受累患者艰难梭状芽胞杆菌感染率显著升高(P0.05);克罗恩病结肠部位受累患者艰难梭状芽胞杆菌感染率显著升高(P0.05)。结论难治性炎症性肠病患者艰难梭状芽胞杆菌感染率较高,与抗菌药物、万古霉素、病情活动度、病情严重度和结肠受累有关。
[Abstract]:Objective to investigate the epidemiology and clinical characteristics of Clostridium difficulty infection in patients with refractory inflammatory bowel disease, and to provide evidence for clinical prevention and treatment of Clostridium diffracta infection. Methods from January 2013 to January 2016, 92 patients with refractory inflammatory bowel disease were selected and detected by fluorescence enzyme immunoassay. To analyze the clinical features of refractory inflammatory bowel disease infected by Clostridium diffcult. Results the infection rate of 19 patients with refractory inflammatory bowel disease was 20.65. The infection rate of ulcerative colitis and Crohn's disease was 20.83 and 20.45 respectively. The infection rate of vancomycin and active refractory inflammatory bowel disease patients was significantly higher (P0.05), and the severity of ulcerative colitis was severe. The infection rate of Clostridium difficulty in moderate and mild patients was 44.445.56% and 8.33%, respectively, the difference was statistically significant (P0.05), the infection rate of Clostridium difficulty was significantly higher in patients with colonic involvement (P0.05), and that in patients with Crohn's disease was difficult (P0.05). The infection rate of Clostridium spp. Conclusion the infection rate of Clostridium difficulty in patients with refractory inflammatory bowel disease is high, which is related to antibiotics, vancomycin, disease activity, severity of disease and colonic involvement.
【作者单位】：浙江大学医学院附属第二医院消化内科;宁波市第七医院消化内科;
【基金】：浙江省医药卫生一般研究计划基金资助项目(2015KYB187)
【分类号】：R574

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