食物不耐受及食物过敏与肠易激综合征的临床研究

发布时间：2018-10-05 13:20

【摘要】：目的:探讨食物特异性Ig G、Ig E与肠易激综合征(irritable bowel syndrome,IBS)的临床关联性。方法:对72例IBS患者和30例正常对照人群应用酶联免疫吸附法,检测其血清中亚洲人常见7种食物不耐受特异性Ig G抗体及8种常见食物过敏特异性Ig E抗体水平。结果:72例IBS患者中食物不耐受特异性Ig G至少1项阳性者48例,阳性率66.7%,显著高于对照组的44.3%(P0.05)。IBS患者中特异性抗体水平等级中度及以上的占45.8%,两种以上食物特异性Ig G阳性的占56.9%。根据检查结果建议IBS患者剔除不耐受食物,8周后IBS症状改善30例(62.5%)。食物过敏特异性Ig E阳性率在IBS组(13.9%)和对照组(13.3%)差异无统计学意义。结论:食物不耐受在IBS的临床发病中起重要作用,可能是IBS的重要因素之一,食物过敏与IBS相关性不大。根据食物不耐受的检查结果建议患者剔除相应食物,可明显改善IBS临床症状。
[Abstract]:Objective: to investigate the relationship between food specific Ig G G E and irritable bowel syndrome (irritable bowel syndrome,IBS). Methods: enzyme linked immunosorbent assay (Elisa) was used in 72 patients with IBS and 30 normal controls to detect the specific Ig G antibodies and Ig E antibodies in the sera of 7 common Asian people and 8 common food allergies. Results among 72 patients with IBS, 48 were positive for food intolerance specific Ig G, the positive rate was 66.7%, which was significantly higher than that in control group (44.3%, P0.05). The specific antibody level was moderate or above in 45.8% of IBS patients, and the positive rate of two or more kinds of food specific Ig G was 56.9%. According to the examination results, 30 cases (62.5%) of IBS patients improved their IBS symptoms after 8 weeks of rejection of food intolerance. There was no significant difference in the positive rate of food allergy specific Ig E between the IBS group (13.9%) and the control group (13.3%). Conclusion: food intolerance plays an important role in the clinical pathogenesis of IBS and may be one of the important factors of IBS. Food allergy has little correlation with IBS. According to the test results of food intolerance, it is suggested that the patients should eliminate the food and improve the clinical symptoms of IBS.
【作者单位】：广州医科大学附属第二医院体检科;广州医科大学附属第二医院变态反应科广东省过敏反应与免疫重点实验室变态反应国家临床重点专科呼吸疾病国家重点实验室;广州医科大学附属第二医院消化内科;
【基金】：广东省科技计划资助项目(2014A020212363)
【分类号】：R574.4

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