不同抗病毒方案治疗慢性乙型肝炎的临床疗效研究

发布时间：2018-10-05 20:12

【摘要】：目的对比不同抗病毒治疗方案针对不同时期慢性乙型肝炎的临床疗效,寻找乙型肝炎治疗的更优方案,提高治疗水平。方法收集2010年6月-2013年12月收治的108例慢性乙型肝炎患者临床资料,依据慢性乙型肝炎分期标准分为免疫清除期54例患者作为观察组,免疫耐受期54例患者作为对照组,分别采用干扰素-α法、恩替卡韦法及联合治疗3种不同的抗病毒治疗方法,疗程均为48周;观察两组患者采用3种方法治疗后肝功能、HBV-DNA定量及乙型肝炎病毒血清标志物等指标,对比3种方法的治疗效果,采用SPSS15.0软件进行统计分析。结果 3种方法治疗后24、48周观察组患者血清HBV-DNA水平、门冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆红素水平均低于对照组(P0.05);联合治疗方法治疗后48周观察组患者肝功复常率及HBV-DNA、HBeAg转阴率均优于两种单独的治疗方案(P0.05)。结论免疫清除期是接受治疗的重要时期,药物恩替卡韦和干扰素联合使用治疗慢性乙型肝炎的效果明显优于单独一种抗病毒药物的治疗,同时可以避免出现耐药性,因此选择免疫清除期采用联合给药方法有利于慢性乙型肝炎的治疗。
[Abstract]:Objective to compare the clinical efficacy of different antiviral therapy for chronic hepatitis B in different periods, and to find a better treatment for hepatitis B and to improve the treatment level. Methods the clinical data of 108 patients with chronic hepatitis B were collected from June 2010 to December 2013. According to the staging criteria of chronic hepatitis B, 54 patients with immune clearance were divided into observation group and 54 patients with immune tolerance as control group. Interferon-伪 method, entecavir method and combined therapy were used for 48 weeks, respectively. The serum markers of hepatitis B virus and HBV-DNA of liver function were measured. To compare the therapeutic effects of the three methods, SPSS15.0 software was used for statistical analysis. Results the serum levels of HBV-DNA, aspartate aminotransferase, alanine aminotransferase, and alanine aminotransferase were measured in the observation group after 24 weeks of treatment. Total bilirubin levels were lower than the control group (P0.05); the observation group 48 weeks after the treatment of liver function recovery rate and HBV-DNA,HBeAg negative rate were better than the two treatment alone (P0.05). Conclusion Immunoclearance is an important period of treatment. The efficacy of combined use of entecavir and interferon in the treatment of chronic hepatitis B is better than that in the treatment of chronic hepatitis B with a single antiviral drug, and drug resistance can be avoided at the same time. Therefore, the combined administration of immunoclearance is beneficial to the treatment of chronic hepatitis B.
【作者单位】：浙江省平阳县人民医院感染科;
【基金】：浙江省卫生厅规划基金资助项目(ZW-2010B-027)
【分类号】：R512.62

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