早期肠内营养对肥胖重症急性胰腺炎预后的影响

发布时间：2018-10-07 19:08

【摘要】：目的探讨早期肠内营养对肥胖重症胰腺炎预后的影响。方法将98例肥胖胰腺炎患者纳入观察组和对照组。观察组在入院24h内经鼻空肠管给予早期肠内营养;对照组在入院48h后,按需经口进食或鼻空肠管给予延迟肠内营养。比较两组患者局部并发症(急性液体积聚,急性坏死物积聚,胰腺假性囊肿,包裹性坏死、胰腺脓肿)、全身并发症(呼吸功能衰竭、循环衰竭、肾衰竭)的发生率、全身炎症反应综合征(SIRS)的发生率及病死率。结果观察组及对照组的总并发症发生率、SIRS发生率、病死率分别为:20.41%、10.20%、6.12%和38.78%、26.53%、22.45%,差异有统计学意义(P0.05)。与对照组相比,观察组入院治疗2周时的外周血WBC计数、C反应蛋白水平均较低,治疗有效率更高、住院时间更短、住院总费用更低,差异均有统计学差异(P0.05)。结论早期肠内营养可降低肥胖重症急性胰腺炎患者总并发症率、SIRS发生率及病死率。
[Abstract]:Objective to investigate the effect of early enteral nutrition on prognosis of obese severe pancreatitis. Methods 98 patients with obese pancreatitis were included in observation group and control group. The observation group was given early enteral nutrition by naso-jejunal tube within 24 hours after admission, while the control group was given delayed enteral nutrition through mouth or naso-jejunum tube after 48 hours of admission. The incidence of local complications (acute fluid accumulation, acute necrotic accumulation, pancreatic pseudocyst, encapsulated necrosis, pancreatic abscess) and systemic complications (respiratory failure, circulatory failure, renal failure) were compared between the two groups. Incidence and mortality of systemic inflammatory response syndrome (SIRS). Results the incidence of Sirs and the mortality of Sirs in the observation group and control group were 10.20% and 22.45%, respectively, and there were significant differences (P0.05) between the observation group and the control group (10. 20% and 38. 78%, 26. 53% and 22. 45%, respectively). Compared with the control group, the levels of WBC count and C-reactive protein in peripheral blood were lower, the effective rate was higher, the hospitalization time was shorter, and the total hospitalization cost was lower in the observation group than in the control group (P0.05). Conclusion early enteral nutrition can reduce the total complication rate, Sirs incidence and mortality in obese patients with severe acute pancreatitis.
【作者单位】：重庆医科大学附属第二医院肝胆外科;重庆医科大学附属第二医院体检中心;
【基金】：重庆市卫计委医学科研计划项目(20142036)
【分类号】：R576

【相似文献】