平均血小板体积在急性胆源性和非胆源性胰腺炎中的临床应用

发布时间：2018-10-08 20:40

【摘要】：目的分析平均血小板体积(MPV)在胆源性与非胆源性急性胰腺炎之间的关系,探讨MPV能否作鉴别急性胰腺炎病因的参考指标。方法检测55例胆源性胰腺炎与57例非胆源性胰腺炎患者的血清生化指标和全血的MPV值,比较两种类型胰腺炎各指标间的相关性。结果谷氨酸丙酮酸转氨酶、天门冬氨酸氨基转移酶、碱性磷酸酶、谷氨酰转肽酶、淀粉酶、脂肪酶等酶类以及总胆红素和直接胆红素在胆源性与非胆源性急性胰腺炎之间差异有统计学意义(P0.05),且浓度水平在胆源性胰腺炎组中较非胆源性胰腺炎组中高。胆源性胰腺炎组和非胆源性胰腺炎组在血小板和MPV之间的差异有统计学意义(P0.05)。MPV在胆源性胰腺炎组中较非胆源性胰腺炎组中高。受试者工作特征曲线显示,在鉴别胆源性胰腺炎组和非胆源性胰腺炎组的MPV曲线下面积为0.746;当MPV的cut-off值为8.33时,判断胆源性胰腺炎组的敏感性和特异性分别为78.6%和62.3%。结论部分酶类指标的差异显示胆源性胰腺炎比非胆源性胰腺炎对相关器官组织的损伤较重,病情更加复杂;胆源性胰腺炎组的MPV值较非胆源性胰腺炎组高,提示MPV可以作为鉴别急性胰腺炎病因的一种简便实用的参考指标。
[Abstract]:Objective to analyze the relationship between gallstone and non-biliary acute pancreatitis with mean platelet volume (MPV) and to explore whether MPV can be used as a reference index to differentiate the etiology of acute pancreatitis. Methods Serum biochemical indexes and MPV values of whole blood were measured in 55 cases of biliary pancreatitis and 57 cases of non-biliary pancreatitis, and the correlation between the two types of pancreatitis was compared. Results glutamic acid pyruvate transaminase, aspartate aminotransferase, alkaline phosphatase, glutamyl transpeptidase, amylase, Lipase and other enzymes, total bilirubin and direct bilirubin were significantly different between biliary and non-biliary acute pancreatitis (P0.05), and the concentration level was higher in the gallstone pancreatitis group than in the non-biliary pancreatitis group. The difference of platelets and MPV between gallstone pancreatitis group and non-biliary pancreatitis group was statistically significant (P0.05) .MPV was higher in gallstone pancreatitis group than in non-biliary pancreatitis group. The operating characteristic curve showed that the area under the MPV curve was 0.746 in differentiating the gallstone pancreatitis group from the non-biliary pancreatitis group, and when the cut-off value of MPV was 8.33, the sensitivity and specificity were 78.6% and 62.3%, respectively. Conclusion the difference of some enzyme indexes shows that the injury of related organs and tissues is more serious in gallstone pancreatitis than that in non-biliary pancreatitis, and the MPV value in gallstone pancreatitis group is higher than that in non-biliary pancreatitis group, and the MPV value in gallstone pancreatitis group is higher than that in non-biliary pancreatitis group. The results suggest that MPV can be used as a simple and practical index to distinguish the etiology of acute pancreatitis.
【作者单位】：安徽医科大学第二附属医院检验科;安徽医科大学第二附属医院急诊外科;
【基金】：安徽省自然科学基金(编号:1508085SMH225)
【分类号】：R446.1;R576

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