酒精性肝硬化患者血清脂联素水平检测及意义探究
发布时间：2018-10-12 19:28
【摘要】：目的：分析酒精性肝硬化患者血清脂联素水平检测的意义。 方法：选取金乡人民医院感染科2013年4月-2013年12月住院肝硬化病人78例。其中酒精性肝硬化患者43例,按child-Pugh分级标准再分为：1.肝功能A级9人,2.肝功能B级21人,3.肝功能C级13人：乙肝肝硬化患者35例；健康对照者20例。采用酶联免疫法测定脂联素,自动生化分析仪测定肝功能,化学发光法检测肝纤维化指标,分析酒精性肝硬化患者血清脂联素水平的变化以及脂联素水平与肝功能、肝纤维化指标的相关性。 结果：与健康对照组比较,乙肝肝硬化患者血清脂联素水平无明显变化(p0.05)；酒精性肝硬化组脂联素水平明显高于对照组(p0.05),并且随着肝硬化逐渐加重,脂联素水平从Child-Pugh A级至C级呈依次递增趋势。(p0.05或0.01)。酒精性肝硬化患者血清脂联素水平与PC-III(r=628)、LN(r=563)、C-IV (r=602)、 HA (r=587)、TBIL (r=0.412)呈正相关(p0.05),与ALB呈负相关(r=-0.609,p0.05)。 结论：酒精性肝硬化患者血清脂联素水平明显升高。且随肝硬化逐渐加重,脂联素水平依次递增。脂联素水平与PC-Ⅲ、LN、C-Ⅳ、HA、TBIL呈正相关,与ALB呈负相关。
[Abstract]:Objective: to analyze the significance of serum adiponectin level in patients with alcoholic cirrhosis. Methods: 78 inpatients with liver cirrhosis from April 2013 to December 2013 in Jinxiang people's Hospital infection Department were selected. Among them, 43 cases of alcoholic cirrhosis were subdivided according to child-Pugh classification standard: 1. Liver function A grade 9, 2. Liver function B grade 21, 3. 13 patients with grade C liver function: 35 patients with hepatitis B cirrhosis and 20 healthy controls. The levels of adiponectin, liver function and liver function were determined by enzyme linked immunosorbent assay (Elisa), automatic biochemistry analyzer and chemiluminescent method, and the changes of serum adiponectin and hepatic function in patients with alcoholic cirrhosis were analyzed. Correlation of hepatic fibrosis index. Results: compared with the healthy control group, the serum adiponectin level in the patients with hepatitis B cirrhosis had no significant change (p0.05), and the adiponectin level in the alcoholic cirrhosis group was significantly higher than that in the control group (p0.05). The level of adiponectin increased from Child-Pugh A to C (p0. 05 or 0. 01). The serum adiponectin level in alcoholic cirrhosis patients was positively correlated with PC-III (rt628), LN (rn563), C-IV (rt602), HA (rn587), TBIL (r0. 412) (p0. 05), and negatively correlated with ALB (r-0. 609? p0. 05). Conclusion: the serum adiponectin level in alcoholic cirrhosis patients is significantly increased. The adiponectin level increased with the exacerbation of cirrhosis. Adiponectin levels were positively correlated with PC- 鈪，
本文编号：2267327
[Abstract]:Objective: to analyze the significance of serum adiponectin level in patients with alcoholic cirrhosis. Methods: 78 inpatients with liver cirrhosis from April 2013 to December 2013 in Jinxiang people's Hospital infection Department were selected. Among them, 43 cases of alcoholic cirrhosis were subdivided according to child-Pugh classification standard: 1. Liver function A grade 9, 2. Liver function B grade 21, 3. 13 patients with grade C liver function: 35 patients with hepatitis B cirrhosis and 20 healthy controls. The levels of adiponectin, liver function and liver function were determined by enzyme linked immunosorbent assay (Elisa), automatic biochemistry analyzer and chemiluminescent method, and the changes of serum adiponectin and hepatic function in patients with alcoholic cirrhosis were analyzed. Correlation of hepatic fibrosis index. Results: compared with the healthy control group, the serum adiponectin level in the patients with hepatitis B cirrhosis had no significant change (p0.05), and the adiponectin level in the alcoholic cirrhosis group was significantly higher than that in the control group (p0.05). The level of adiponectin increased from Child-Pugh A to C (p0. 05 or 0. 01). The serum adiponectin level in alcoholic cirrhosis patients was positively correlated with PC-III (rt628), LN (rn563), C-IV (rt602), HA (rn587), TBIL (r0. 412) (p0. 05), and negatively correlated with ALB (r-0. 609? p0. 05). Conclusion: the serum adiponectin level in alcoholic cirrhosis patients is significantly increased. The adiponectin level increased with the exacerbation of cirrhosis. Adiponectin levels were positively correlated with PC- 鈪，
本文编号：2267327
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