UC患者体内PLT、MPV和D-D水平变化与患者患病的相关性分析
发布时间：2018-10-15 15:37
【摘要】：目的观察溃疡性结肠炎(UC)患者的PLT、MPV和D-D水平,分析其与胃肠激素水平和炎症细胞因子水平的相关性。方法回顾性分析2014年6月至2016年8月在本院接受治疗的溃疡性结肠炎患者的临床资料,根据其疾病分期分为活动期和缓解期,同时选取50例健康成年人作为对照组。观察三组PLT、MPV和D-D、炎症细胞因子和胃肠激素水平的差异,分析PLT、MPV和D-D水平与炎症细胞因子和胃肠激素水平的相关性。结果三组PLT、MPV和D-D水平存在明显差别:PLT和D-D水平由高到低分别为活动期组、稳定期组和对照组,MPV水平由高到低分别为对照组、稳定期组和活动期组;三组的IL-6、IL-10和TNF-α等细胞因子水平由高到低分别为活动期组、稳定期组和对照组;三组的GAS、VIP和MOT水平由高到低分别为对照组、稳定期组和活动期组;PLT和D-D与IL-6、IL-10和TNF-α等炎症细胞因子水平正相关,与GAS、VIP和MOT负相关,MPV与IL-6、IL-10和TNF-α等炎症细胞因子水平负相关,与GAS、VIP和MOT正相关。结论 UC活动期患者的PLT和D-D水平水平较高,MPV水平较低,且与患者的炎症细胞因子和胃肠激素水平密切相关。
[Abstract]:Objective to observe the levels of PLT,MPV and D D in patients with ulcerative colitis (UC) and to analyze their correlation with the levels of gastrointestinal hormones and inflammatory cytokines. Methods the clinical data of patients with ulcerative colitis treated in our hospital from June 2014 to August 2016 were analyzed retrospectively. According to the stages of ulcerative colitis, the patients were divided into active stage and remission stage. 50 healthy adults were selected as control group. The levels of PLT,MPV, D-D, inflammatory cytokines and gastrointestinal hormones in the three groups were observed, and the correlation between PLT,MPV and D-D levels and inflammatory cytokines and gastrointestinal hormones was analyzed. Results there were significant differences in the levels of PLT,MPV and D-D among the three groups: the levels of PLT and D-D from high to low were active group, stable group and control group, and MPV level from high to low were control group, stable group and active phase group; The levels of cytokines such as IL-6,IL-10 and TNF- 伪 in the three groups from high to low were the active phase group, the stable phase group and the control group, and the GAS,VIP and MOT levels of the three groups were the control group from high to low, respectively. PLT and D-D were positively correlated with the levels of inflammatory cytokines such as IL-6,IL-10 and TNF- 伪, GAS,VIP and MOT, MPV and IL-6,IL-10 and TNF- 伪, GAS,VIP and MOT. Conclusion the levels of PLT, D-D and MPV in patients with active UC are higher and lower, and are closely related to the levels of inflammatory cytokines and gastrointestinal hormones.
【作者单位】： 佛山市高明区人民医院ICU;
【分类号】：R574.62
本文编号：2272993
[Abstract]:Objective to observe the levels of PLT,MPV and D D in patients with ulcerative colitis (UC) and to analyze their correlation with the levels of gastrointestinal hormones and inflammatory cytokines. Methods the clinical data of patients with ulcerative colitis treated in our hospital from June 2014 to August 2016 were analyzed retrospectively. According to the stages of ulcerative colitis, the patients were divided into active stage and remission stage. 50 healthy adults were selected as control group. The levels of PLT,MPV, D-D, inflammatory cytokines and gastrointestinal hormones in the three groups were observed, and the correlation between PLT,MPV and D-D levels and inflammatory cytokines and gastrointestinal hormones was analyzed. Results there were significant differences in the levels of PLT,MPV and D-D among the three groups: the levels of PLT and D-D from high to low were active group, stable group and control group, and MPV level from high to low were control group, stable group and active phase group; The levels of cytokines such as IL-6,IL-10 and TNF- 伪 in the three groups from high to low were the active phase group, the stable phase group and the control group, and the GAS,VIP and MOT levels of the three groups were the control group from high to low, respectively. PLT and D-D were positively correlated with the levels of inflammatory cytokines such as IL-6,IL-10 and TNF- 伪, GAS,VIP and MOT, MPV and IL-6,IL-10 and TNF- 伪, GAS,VIP and MOT. Conclusion the levels of PLT, D-D and MPV in patients with active UC are higher and lower, and are closely related to the levels of inflammatory cytokines and gastrointestinal hormones.
【作者单位】： 佛山市高明区人民医院ICU;
【分类号】：R574.62
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