探讨奥美拉唑治疗胃溃疡的药理作用和临床效果

发布时间：2018-10-15 18:00

【摘要】：本研究将82例胃溃疡患者根据随机数字表分为两组。予以对照组盐酸雷尼替丁治疗,予以观察组奥美拉唑治疗。对比两组治疗前后的疗效及患者IL-2、IL-6、CRP、TNF-α、SOD、VEGF、EGF的水平变化之后,结果发现观察组有效率明显高于对照组,差异有统计学意义(p0.05);两组治疗前的IL-2、IL-6、CRP水平差异无统计学意义(p0.05);治疗后的IL-6、CRP水平较治疗前降低,IL-2水平较治疗前升高,且观察组较对照组变化明显(p0.05);两组治疗前的TNF-α、SOD、VEGF、EGF水平差异无统计学意义(p0.05);治疗后的TNF-α水平较治疗前降低,SOD、VEGF、EGF水平较治疗前高,且观察组比对照组的变化明显(p0.05)。提示奥美拉唑在治疗胃溃疡方面效果显著,可改善炎症反应,快速修复溃疡面,是治疗胃溃疡的有效药物。
[Abstract]:82 patients with gastric ulcer were randomly divided into two groups. The control group was treated with ranitidine hydrochloride and the observation group with omeprazole. After comparing the curative effect before and after treatment and the changes of IL-2,IL-6,CRP,TNF- 伪 and SOD,VEGF,EGF levels in the two groups, the results showed that the effective rate in the observation group was significantly higher than that in the control group. The difference was statistically significant (p0. 05), there was no significant difference in IL-2,IL-6,CRP level between the two groups before treatment (p0. 05), the IL-6,CRP level after treatment was lower than that before treatment, and the IL-2 level was higher than that before treatment. The levels of TNF- 伪 and SOD,VEGF,EGF in the observation group were significantly higher than those in the control group (p0.05), the levels of TNF- 伪 and SOD,VEGF,EGF in the observation group were significantly higher than those in the control group (p0.05), and the levels of TNF- 伪 in the observation group were significantly higher than those in the control group (p0.05). It is suggested that omeprazole is an effective drug for the treatment of gastric ulcer.
【作者单位】：延安大学西安创新学院;
【基金】：延安大学西安创新学院提供项目资助
【分类号】：R573.1

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