南京市鼓楼区居民胆囊疾病与胰岛功能及糖尿病发生风险的研究

发布时间：2018-10-20 07:42

【摘要】：目的:探索南京市鼓楼区居民胆囊疾病与胰岛素抵抗、胰岛β细胞功能的关系以及胆囊疾病患者的糖尿病发生风险。方法:对南京市鼓楼区8 180例既往无糖尿病的居民进行问卷调查、体格检查、血样采集、口服糖耐量试验(OGTT)及胰岛素释放试验。分析胆囊疾病各组的特征,比较各组胰岛素抵抗与胰岛β细胞功能指标,分析胆囊疾病患者糖尿病风险。结果:性别、年龄、血压、体重指数(BMI)、腰臀比(WHR)、负荷后血糖、糖化血红蛋白(Hb A1c)、血脂、肝酶、生活方式及糖尿病发病率在无胆囊疾病、胆囊疾病未手术及胆囊疾病术后3组的分布不同。2组胆囊疾病患者胰岛素敏感性指标胰岛素抵抗(HOMA-IR)、胰岛素敏感指数(ISI)、胰岛素释放指数(INSR120)与无胆囊疾病者的差异有统计学意义(P0.05)。胆囊疾病手术后糖尿病及代谢综合征风险增加。结论:胆囊疾病在既往无糖尿病史的南京市鼓楼区居民中是胰岛素抵抗的标志,胆囊疾病术后状态是糖尿病的危险因素。
[Abstract]:Objective: to explore the relationship between gallbladder disease and insulin resistance, 尾-cell function and diabetes risk of patients with gallbladder disease in Gulou District of Nanjing. Methods: a questionnaire survey, physical examination, blood sample collection, oral glucose tolerance test (OGTT) and insulin release test were conducted in 8 180 residents of Gulou District, Nanjing. The characteristics of each group of gallbladder disease were analyzed, insulin resistance and islet 尾 -cell function were compared in each group, and the risk of diabetes in patients with gallbladder disease was analyzed. Results: sex, age, blood pressure, body mass index (BMI), waist hip ratio (WHR), blood glucose, Hb A1c, blood lipid, liver enzyme, lifestyle and the incidence of diabetes were not found in patients with gallbladder disease. The distribution of insulin sensitivity index (HOMA-IR), insulin sensitivity index (ISI),) and insulin release index (INSR120) in patients with gallbladder disease were significantly different from those without gallbladder disease (P0.05). Increased risk of diabetes and metabolic syndrome after cholecystectomy. Conclusion: gallbladder disease is a marker of insulin resistance in residents of Gulou District of Nanjing without diabetes. Postoperative status of gallbladder disease is a risk factor of diabetes.
【作者单位】：南京医科大学第一附属医院内分泌科;上海交通大学医学院附属瑞金医院国家代谢病临床研究中心;
【基金】：国家代谢性疾病临床医学研究中心项目(2013BAI09B13) 科技部重大新药创制项目(2012ZX09303006-001)
【分类号】：R587.1;R575.6

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