乌司他丁治疗老年重症急性胰腺炎并腹内高压的临床效果及对血清学指标的影响

发布时间：2018-10-26 18:33

【摘要】：目的探讨乌司他丁治疗老年重症急性胰腺炎并腹内高压临床效果以及对血清学指标影响。方法选择80例老年重症急性胰腺炎并腹内高压患者,按照数字表法随机分为观察组与对照组,各40例。对照组使用基础治疗,观察组在对照组基础上使用乌司他丁治疗,对比两组治疗后有效率,治疗前后肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、-10、腹内压(IAP)等临床指标。结果观察组治疗有效率为90.00%,明显高于对照组70.00%(χ2=5.000,P0.05);两组患者治疗后TNF-α、IL-6、IL-10较治疗前均有明显改善(P0.05);观察组治疗后相比对照组改善更明显(P0.05);两组患者治疗后IAP、免疫球蛋白(Ig)A、二胺氧化酶(DAO)相比治疗前均有明显改善(P0.05);观察组治疗后IAP、Ig A、DAO相比对照组改善更明显(P0.05)。结论乌司他丁治疗老年重症急性胰腺炎并腹内高压临床效果好,利于改善IAP以及肠黏膜功能,值得临床推广应用。
[Abstract]:Objective to investigate the clinical effect of ulinastatin in the treatment of elderly severe acute pancreatitis with intraabdominal hypertension and its influence on serological indexes. Methods Eighty elderly patients with severe acute pancreatitis complicated with intraabdominal hypertension were randomly divided into observation group (n = 40) and control group (n = 40). The control group was treated with basic therapy, the observation group was treated with ulinastatin on the basis of the control group, and the effective rate was compared between the two groups. Before and after treatment, tumor necrosis factor (TNF)-伪 and interleukin (IL)-6 were used in the observation group. Intraabdominal pressure (IAP) and other clinical indicators. Results the effective rate of treatment in the observation group was 90.00g / kg, which was significantly higher than that in the control group (70.00%) (蠂 2 5.000 P 0.05), the TNF- 伪 and IL-6,IL-10 of the two groups were significantly improved after treatment (P0.05). After treatment, IAP, immunoglobulin (Ig) A, diamine oxidase (DAO) was significantly improved in the observation group than in the control group (P0.05). IAP,Ig Agnadao in the observation group was significantly improved compared with the control group (P0.05). Conclusion ulinastatin is effective in the treatment of elderly patients with severe acute pancreatitis and intraabdominal hypertension. It is beneficial to improve IAP and intestinal mucosal function and is worthy of clinical application.
【作者单位】：浙江衢化医院消化内科;
【分类号】：R576

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