双联抗血小板治疗相关上消化道出血的临床特征

发布时间：2018-10-31 16:46

【摘要】：目的研究双联抗血小板治疗相关上消化道出血(UGIB)的临床特点。方法收集双联抗血小板治疗相关UGIB住院患者59例为观察组,随机选取同期非抗血小板治疗的UGIB患者120例作为对照组,对两组患者的临床资料进行比较。结果两组患者在性别、贫血程度、幽门螺杆菌感染等方面无显著差异(P0.05)。但是观察组患者的年龄较对照组高(P=0.000),观察组出血之前缺乏典型腹痛症状者明显增多(P=0.000),出血症状中缺乏呕血和黑便症状,仅以乏力贫血就诊者明显增多(P=0.001)。观察组内镜表现为黏膜糜烂患者增多,但无统计学差异(P=0.269)。观察组患者均合并冠心病,57.63%合并急性冠脉综合征,与对照组有显著差异(均P=0.000)。观察组住院时间明显延长(P=0.000),病死率明显增高(P=0.023)。结论应加强对双联抗血小板治疗相关UGIB临床特点的认识,减少抗血小板药物不良反应。
[Abstract]:Objective to study the clinical features of (UGIB) associated with dual antiplatelet therapy for upper gastrointestinal hemorrhage. Methods Fifty-nine inpatients with UGIB associated with dual antiplatelet therapy were selected as observation group and 120 UGIB patients who were not treated with anti-platelet therapy were randomly selected as control group. The clinical data of the two groups were compared. Results there was no significant difference in sex, anemia and Helicobacter pylori infection between the two groups (P0.05). However, the age of the patients in the observation group was higher than that in the control group (P0. 000). The number of patients without typical abdominal pain before bleeding in the observation group increased significantly (P0. 000). The number of patients with anemic anemia increased significantly (P0. 001). The endoscopic manifestations of the observation group were increased, but there was no statistical difference (P < 0. 269). All the patients in the observation group were complicated with coronary heart disease, 57.63% of the patients were complicated with acute coronary syndrome, and there was a significant difference between the observation group and the control group (P < 0. 000). In the observation group, the length of hospital stay was prolonged (P0. 000) and the mortality was increased (P0. 023). Conclusion the clinical characteristics of UGIB associated with dual antiplatelet therapy should be strengthened to reduce the adverse effects of antiplatelet drugs.
【作者单位】：天津医科大学第四中心临床学院天津市第四中心医院消化内科;天津医科大学总医院消化科;
【分类号】：R573.2

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