抑制胃酸分泌治疗重症急性胰腺炎的前瞻性随机临床对照研究

发布时间：2018-11-03 17:40

【摘要】：目的探讨抑制胃酸分泌在重症急性胰腺炎(SAP)治疗中的作用。方法收集2015年10月至2016年10月四川大学华西医院消化内科诊治的45例SAP患者,将患者随机分为常规治疗组(C组,21例)与常规治疗+40mg/d艾司奥美拉唑组(C+E组,24例),疗程7d。前瞻性比较1d(基线)、7d血炎症介质[C-反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及降钙素原(PCT)],1d(基线)、3d、7d的临床评分[急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)、全身炎症反应综合征评分(SIRS评分)、改良Marshall评分],7d的胃酸水平、大便便血及溃疡的发生(胃镜下)。结果两组患者基线数据具有可比性;抑酸治疗7d,C+E组胃内pH值高于C组(5.02±1.61vs.2.83±1.08,P0.001);两组患者在血炎症介质水平、各项临床评分、应激溃疡发生及大便隐血诸方面差异均无统计学意义(P0.05)。结论抑制胃酸不能改善SAP患者全身炎症反应程度及临床各项评分,亦无益于预防应激性溃疡及消化道出血。
[Abstract]:Objective to investigate the effect of inhibiting gastric acid secretion in the treatment of severe acute pancreatitis with (SAP). Methods from October 2015 to October 2016, 45 patients with SAP were randomly divided into two groups: routine treatment group (group C, 21 cases) and routine treatment group (C E group, 24 cases). The course of treatment was 7 days. Serum inflammatory mediators [C- reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor- 伪 (TNF- 伪) and procalcitonin (PCT)] were compared prospectively for 1 day (baseline) and 7 days. 1 day (baseline), 3 days and 7 days clinical score [acute physiology and chronic health status scoring system 鈪，

本文编号：2308490