急性胰腺炎患者多种维生素代谢变化及其影响因素的研究
发布时间：2018-11-05 07:30
【摘要】：目的:探讨不同分型急性胰腺炎患者维生素A、B1、B2、B6、B9、B12、C、D、E的浓度变化,分析发病过程中血清维生素浓度变化的相关影响因素。方法:本研究收集111例急性胰腺炎患者作为病例组,根据患者病情轻重将其分为三组:轻症(MAP)组(39例)、中重症(MSAP)组(38例)、重症(SAP)组(34例),同时随机选取37例健康志愿者为对照组。在静脉给予常规推荐剂量维生素的情况下,检测急性胰腺炎患者血清维生素A、B1、B2、B6、B9、B12、C、D、E的浓度、血淀粉酶、电解质、肝肾功、PCT、CRP等血液指标,并计算急性胰腺炎患者床旁严重度指数(BISAP)评分,比较不同分型急性胰腺炎患者多种维生素的浓度差异,利用单因素分析及多元逐步回归分析的方法,分析影响急性胰腺炎患者血清维生素浓度变化的诸多相关影响因素。结果:(1)急性胰腺炎患者血清维生素B1、B2、B6、B9、B12的浓度与健康对照组相比,浓度出现下降趋势,但差别无统计学意义(P0.05)。(2)急性胰腺炎患者血清维生素A、C、D、E浓度均低于健康对照组,差别有统计学意义(P0.05)。其中,SAP组较MAP组维生素A浓度下降,差别有统计学意义(P0.01);MAP组、SMAP组与SAP组相比,维生素C、D、E浓度明显下降,差别均有统计学意义(P0.01)。(3)单因素分析中,急性胰腺炎患者血清维生素C浓度与年龄呈负相关(r=-0.294,P=0.002),随着年龄的增加,维生素C浓度随之降低,而血清维生素A、D、E浓度变化与患者年龄因素无明显相关性。抽血前禁食天数7天的急性胰腺炎患者维生素C浓度显著低于≤7天组,差异有统计学意义,而维生素A、D、E浓度无差异。另外,急性胰腺炎患者血清维生素A、C、D、E浓度与性别、BMI无相关性(P0.05)。(4)通过多元逐步回归分析发现急性胰腺炎患者血清维生素A、C、D、E浓度与患者性别、身高、体重、体质指数、血清白蛋白、白细胞、血红蛋白、CRP、PCT、住院天数均无关,与BISAP评分有关,BISAP评分越高,血清维生素A、C、D、E浓度变化越明显;其中维生素C浓度变化还与抽血前禁食天数、年龄有关。维生素A浓度与BISAP评分的回归方程为y=0.589-0.04x;维生素D浓度与BISAP评分的回归方程为y=76.634-14.917x;维生素E浓度与BISAP评分的回归方程为y=12.16-7.28x;维生素C浓度与BISAP评分(x1)、抽血前禁食天数(x2)、年龄(x3)的回归方程为y=40.019-1.852x1-0.447x2-0.052x3。结论:(1)不同分型急性胰腺炎患者血清维生素A、C、D、E浓度存在统计学差异;(2)急性胰腺炎患者血清维生素A、C、D、E浓度与病情严重程度有关,病情越严重,血清维生素A、C、D、E浓度下降越显著;(3)维生素C浓度变化与抽血前禁食天数及年龄相关。(4)重症急性胰腺炎患者静脉补充常规推荐量的维生素A、C、D、E不能满足发病时机体需要量。
[Abstract]:Objective: to investigate the changes of vitamin A, B _ 1 B _ 2 B _ (2) B _ (6) B _ (9) B _ (12) C _ (1) C _ (C) E in patients with acute pancreatitis of different types and to analyze the related factors influencing the changes of serum vitamin concentration during the onset of acute pancreatitis. Methods: 111 patients with acute pancreatitis were divided into three groups according to the severity of the disease: mild (MAP) group (39 cases), moderate and severe (MSAP) group (38 cases), severe (SAP) group (34 cases). At the same time, 37 healthy volunteers were randomly selected as control group. The concentration of serum vitamin A, B1OB2OB6OB9B9B12, serum amylase, electrolytes, liver and kidney function, PCT,CRP and so on in patients with acute pancreatitis were detected by intravenous administration of routine recommended doses of vitamins. The bedside severity index (BISAP) score of acute pancreatitis patients was calculated, and the multivitamin concentrations in patients with acute pancreatitis were compared by single factor analysis and multivariate stepwise regression analysis. To analyze the influence factors of serum vitamin concentration in patients with acute pancreatitis. Results: (1) the concentration of serum vitamin B1, B2B6, B9, B12 in patients with acute pancreatitis showed a downward trend compared with the healthy control group. But there was no significant difference (P0.05). (2) in acute pancreatitis patients with serum vitamin A,). (E concentrations were lower than the healthy control group, the difference was statistically significant (P0.05). The concentration of vitamin A in SAP group was significantly lower than that in MAP group (P0.01). In MAP group, SMAP group and SAP group, the concentration of vitamin C and DIAE decreased significantly, and the difference was statistically significant (P0.01). (3) in univariate analysis. There was a negative correlation between serum vitamin C concentration and age in patients with acute pancreatitis (r = 0.294P0. 002). With the increase of age, vitamin C concentration decreased, while serum vitamin A, D, There was no significant correlation between E concentration and age factors. The concentration of vitamin C in the patients with acute pancreatitis was significantly lower than that in the group of 鈮，
本文编号：2311347
[Abstract]:Objective: to investigate the changes of vitamin A, B _ 1 B _ 2 B _ (2) B _ (6) B _ (9) B _ (12) C _ (1) C _ (C) E in patients with acute pancreatitis of different types and to analyze the related factors influencing the changes of serum vitamin concentration during the onset of acute pancreatitis. Methods: 111 patients with acute pancreatitis were divided into three groups according to the severity of the disease: mild (MAP) group (39 cases), moderate and severe (MSAP) group (38 cases), severe (SAP) group (34 cases). At the same time, 37 healthy volunteers were randomly selected as control group. The concentration of serum vitamin A, B1OB2OB6OB9B9B12, serum amylase, electrolytes, liver and kidney function, PCT,CRP and so on in patients with acute pancreatitis were detected by intravenous administration of routine recommended doses of vitamins. The bedside severity index (BISAP) score of acute pancreatitis patients was calculated, and the multivitamin concentrations in patients with acute pancreatitis were compared by single factor analysis and multivariate stepwise regression analysis. To analyze the influence factors of serum vitamin concentration in patients with acute pancreatitis. Results: (1) the concentration of serum vitamin B1, B2B6, B9, B12 in patients with acute pancreatitis showed a downward trend compared with the healthy control group. But there was no significant difference (P0.05). (2) in acute pancreatitis patients with serum vitamin A,). (E concentrations were lower than the healthy control group, the difference was statistically significant (P0.05). The concentration of vitamin A in SAP group was significantly lower than that in MAP group (P0.01). In MAP group, SMAP group and SAP group, the concentration of vitamin C and DIAE decreased significantly, and the difference was statistically significant (P0.01). (3) in univariate analysis. There was a negative correlation between serum vitamin C concentration and age in patients with acute pancreatitis (r = 0.294P0. 002). With the increase of age, vitamin C concentration decreased, while serum vitamin A, D, There was no significant correlation between E concentration and age factors. The concentration of vitamin C in the patients with acute pancreatitis was significantly lower than that in the group of 鈮，
本文编号：2311347
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