IVIM-MRI对SD大鼠放疗后肝脏纤维化的实验研究

发布时间：2018-11-05 16:08

【摘要】：目的探讨体素内不相干运动(IVIM)理论的多b值磁共振扩散加权成像(DWI)在大鼠放疗后早期肝纤维化(HF)诊断及分期中的价值。方法将30只雌性SD大鼠随机分为3组,对右半肝分别进行1、2、3个月放疗,以制备不同病理分期的放射性大鼠肝纤维化模型。于放疗前、放疗后1、2、3个月分别对SD大鼠进行磁共振T1WI、T2WI、多b值DWI序列扫描,测量放疗前后不同时间点肝脏左右叶ADC、D、D*、f值。在放疗后的每个时间点MRI检查扫描完成后即刻处死大鼠并取病理标本。结果各时间点放疗后与放疗前对比,肝右叶ADC值与D值降低,其差别均有统计学意义(P0.05);ADC值与D值与HF病理分期呈中度负相关;D*值及f值的差别无统计学意义(P0.05)。结论放疗后早期HF在常规MRI序列上未见改变,ADC及D值能准确反映早期HF的严重程度,为活体评价早期HF的重要指标。
[Abstract]:Objective to investigate the value of (IVIM) theory of voxel incoherent motion in the diagnosis and staging of early hepatic fibrosis in rats with diffusion-weighted multi-b magnetic resonance imaging (DWI). Methods Thirty female SD rats were randomly divided into 3 groups. The right half liver was treated with radiotherapy for 1 and 3 months, respectively. SD rats were examined with T1WII T2WI and multi-b DWI sequence before and after radiotherapy. The ADC,D,D*,f values of left and right lobes of liver were measured at different time points before and after radiotherapy. The rats were killed and pathological specimens were taken at each time point after radiotherapy by MRI scan. Results the ADC value and D value of right lobe of liver decreased after radiotherapy and before radiotherapy at each time point, and the difference was statistically significant (P0.05); ADC and D were negatively correlated with HF pathological stage). There was no significant difference between D * value and f value (P0.05). Conclusion there is no change of HF in routine MRI sequence after radiotherapy. ADC and D values can accurately reflect the severity of early HF, which is an important index for evaluating early HF in vivo.
【作者单位】：暨南大学附属第一医院影像中心;
【分类号】：R445.2;R575.2

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