雷贝拉唑钠肠溶片在幽门螺杆菌阳性十二指肠溃疡中的疗效、安全性及优势分析

发布时间：2018-11-11 17:42

【摘要】：目的:探讨雷贝拉唑钠在幽门螺杆菌阳性十二指肠溃疡患者中的应用效果、安全性及临床优势。方法:将122例十二指肠溃疡患者作为研究对象,所选患者均行13 C呼吸试验并确定幽门螺杆菌阳性,经随机数字表法将全部患者分为2组,即观察组行"雷贝拉唑钠+阿莫西林克拉维酸钾+甲硝唑"的三联治疗,对照组行"奥美拉唑+阿莫西林克拉维酸钾+甲硝唑"的传统三联治疗,综合比较2组患者溃疡治疗效果、幽门螺杆菌根除情况及药物安全性。结果:经治疗2周后,观察组溃疡愈合率为90.16%,高于对照组(75.41%)(P0.05);经治疗后2组患者镜下溃疡面积较治疗前均明显缩小(P0.01);观察组幽门螺杆菌根除率达到95.08%;对照组为81.97%,2组幽门螺杆菌根除率比较差异有统计学意义(P0.05);2组患者不良反应发生率比较差异无统计学意义(P0.05);药物经济学方面,观察组C/E值为8.5明显优于对照组。结论:雷贝拉唑钠用于临床治疗幽门螺杆菌阳性十二指肠溃疡具有溃疡愈合率高、幽门螺杆菌根除彻底、安全性高等优势,值得临床推广应用。
[Abstract]:Objective: to investigate the efficacy, safety and clinical advantages of rabeprazole sodium in patients with Helicobacter pylori positive duodenal ulcer. Methods: 122 patients with duodenal ulcer were randomly divided into two groups, all of whom underwent 13 C respiratory test and were confirmed to be positive for Helicobacter pylori. The observation group was treated with the triple therapy of "Rabeprazole sodium amoxicillin clavulanidate potassium metronidazole" and the control group with the traditional triple treatment of "omeprazole amoxicillin clavulanidate potassium metronidazole". The curative effect of ulcer, eradication of Helicobacter pylori and drug safety were compared. Results: after 2 weeks of treatment, the healing rate of ulcer in the observation group was 90.16, which was higher than that in the control group (75.41%) (P0.05), and the area of ulcers in the two groups was significantly smaller than that before treatment (P0.01). The eradication rate of Helicobacter pylori in the observation group was 95.08 and that in the control group was 81.97. There was significant difference in the eradication rate of Helicobacter pylori between the two groups (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). In terms of pharmacoeconomics, the C / E value of the observation group was 8.5 significantly better than that of the control group. Conclusion: rabeprazole sodium in the treatment of Helicobacter pylori positive duodenal ulcer has the advantages of high ulcer healing rate, complete eradication of Helicobacter pylori and high safety.
【作者单位】：浙江省仙居县城关中心卫生院消化内科;浙江省台州医院消化内科;
【分类号】：R573.1

【参考文献】