医院集中监测药物性肝损害及其危险因素相关性研究

发布时间：2018-11-16 18:33

【摘要】：目的:为临床合理用药及避免药物性肝损害提供参考。方法:利用医院集中监测方法,回顾性分析某院2012年7月-2013年6月所有住院病历,发掘出药物性肝损害病例121例,详细记录患者资料,归纳、总结出引发药物性肝损害的药品种类,并对其危险因素进行分析。结果:引发药物性肝损害前3类药物分别是抗菌药物、抗肿瘤药和中成药;性别与年龄、过敏体质、烟酒史、肝病史和免疫力低下是引起药物性肝损害的危险因素。临床表现以肝细胞损害型最为常见,有64例(占52.89%)。结论:引发药物性肝损害的药品种类较多,应严格把握用药指征,尽量避免联合用药,对老年和存在危险因素患者应权衡利弊决定用药方案。
[Abstract]:Objective: to provide reference for clinical rational use of drugs and prevention of drug-induced liver damage. Methods: by means of centralized monitoring in hospital, all the medical records of a hospital from July 2012 to June 2013 were retrospectively analyzed, 121 cases of drug-induced liver damage were found out, and the data of the patients were recorded and summarized in detail. The types of drugs causing drug-induced liver damage were summarized and the risk factors were analyzed. Results: the first three kinds of drugs causing drug-induced liver injury were antimicrobial drugs, antitumor drugs and Chinese patent drugs, sex and age, allergic constitution, history of tobacco and alcohol, history of liver disease and low immunity were the risk factors of drug-induced liver damage. The most common clinical manifestation was hepatocyte damage, 64 cases (52.89%). Conclusion: there are many kinds of drugs that cause drug-induced liver damage. The indication of drug use should be strictly grasped, the combination of drugs should be avoided as far as possible, and the medication scheme should be determined by weighing the advantages and disadvantages of the elderly patients and patients with risk factors.
【作者单位】： 中山市人民医院;
【基金】：中山市卫生局医学科研立项课题和新技术新项目推广应用项目(No.2013J050)
【分类号】：R575

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