鲁南地区消化性溃疡患者发病影响因素的调查研究

发布时间：2018-12-19 15:44

【摘要】：目的通过对山东省鲁南地区消化性溃疡患者的基本资料、生活饮食习惯、临床特点等进行综合研究,分析出该地区消化性溃疡发病的主要相关因素,为该地区消化性溃疡的临床预防、诊断与治疗提供参考。方法应用以医院为基础的病例-对照研究方法,根据统一的入组与排除标准,进行病例收集。随机选取2012年1月~2013年6月滕州市中心人民医院入院诊治的确诊为消化性溃疡的患者318例、设为实验组,并随机选取同期滕州市中心人民医院体检的健康人群420例、设为对照组。对上述研究对象的基本资料、生活饮食习惯、口服药物史、精神心理因素等进行问卷调查与指标分析。所有数据经Epidata3.1建库分析,并应用SPSS软件行单因素、多因素分析。结果1、单因素分析1.1实验组男性占该组72.96%(232人),女性占该组27.04%(86人),对照组男性占该组52.62%(221人)、女性占该组47.38%(199人),差异显著(P0.05);实验组体力劳动69.50%、脑力劳动30.50%,对照组分别为30.00%、70.00%,差异显著(P0.05);实验组溃疡出血史88.05%、心脑血管病史79.56%、PU既往史88.36%、自身免疫疾病史1.89%,对照组分别为69.29%、54.76%、67.86%、0.95%,差异显著(P0.05);实验组Hp感染69.50%,对照组51.90%,差异显著(P0.05);两组年龄、学历构成具可比性,但无显著差异(P0.05)。1.2实验组吸烟64.47%、饮酒31.13%、生活规律61.01%、饮食规律55.97%,对照组吸烟53.10%、饮酒18.57%、生活规律21.67%、饮食规律72.14%,两组差异显著(P0.05);两组睡眠时间具可比性,但无显著差异(P0.05)。详见表3。膳食调查中,实验组与对照组差异显著(P0.05)的有煎炸食品、熏烤腌制食品、辛辣食品、浓茶咖啡、牛奶。1.3实验组SCL-90中9个因子的项目评分≥3的有焦虑(100.00%)、抑郁(100.00%)、人际关系敏感(80.00%)、强迫症(50.00%)、敌对(40.00%),对照组分别为焦虑(30.00%)、人际关系敏感(30.00%),两组差异显著(P0.05);详见表5。实验组HAMA评分为2.58±1.17、HAMD评分为12.38±3.68,对照组分别为1.06±0.25、5.88±0.76,两组差异显著(P0.05)。1.4实验组NSAIDs未服药66.67%、短期服药13.20%、长期服药20.13%;对照组分别为90.47%、5.48%、4.05%,两组差异显著(P0.05)。2、多因素分析经Logistic多因素回归分析,影响PU发病的因素有心脑血管病史、Hp感染、吸烟、生活不规律、饮食不规律、辛辣食品、浓茶咖啡、牛奶、焦虑、抑郁、NSAIDs服药史,其中牛奶为保护因素。结论1、影响鲁南地区PU发病的相关因素有性别、职业、心脑血管病史、NSAIDs类等药物、Hp感染、吸烟、饮酒、生活不规律、饮食不规律、煎炸食品、熏烤腌制食品、辛辣坚硬食品、浓茶咖啡、牛奶、焦虑抑郁等精神心理、NSAIDs服药史,其中牛奶为保护因素。2、保持良好的生活习惯和方式,比如生活规律,戒除烟酒等不良嗜好、合理膳食,避免长期、大量进食辛辣腌制食品,减少煎饼等干硬食物,避免不合理使用NSAIDs类等药物,均有利于鲁南地区PU的预防和治疗。
[Abstract]:Objective to analyze the main related factors of peptic ulcer in southern Shandong province through comprehensive study on the basic data, diet habits and clinical characteristics of peptic ulcer patients in this area. To provide reference for clinical prevention, diagnosis and treatment of peptic ulcer in this area. Methods Hospital-based case-control study was used to collect cases according to the standard of admission and exclusion. From January 2012 to June 2013, 318 patients with peptic ulcer were randomly selected from Teng Zhou Central people's Hospital as experimental group, and 420 healthy people who were examined in Tengzhou Central people's Hospital during the same period were randomly selected. Control group was set up. The basic data, diet habits, oral drug history, psycho-psychological factors and so on were investigated by questionnaire and index analysis. All the data were analyzed by Epidata3.1 and single factor and multi-factor analysis with SPSS software. Results 1. Univariate analysis 1.1 male accounted for 72.96% (232), female 27.04% (86), control group 52.62% (221), female 47.38% (199). The difference was significant (P0.05). In the experimental group, the physical labor was 69.50 and the mental work was 30.50. In the control group, the difference was significant (P0.05). The bleeding history of ulcer in the experimental group was 88.05, the history of cardiovascular and cerebrovascular diseases was 88.36, the history of autoimmune disease was 1.89, and the control group was 69.29 and 67.860.95, respectively. The difference was significant (P0.05). Hp infection was 69.50 in the experimental group and 51.90 in the control group (P0.05). There was no significant difference between the two groups in terms of age and educational background (P0.05). 1.2 the experimental group smoked 64.47, the drinking 31.13my, the living law 61.01a, the diet 55.97, the control group 53.100.The two groups had significant differences in age and academic background (P0.05). Drinking 18.57, living law 21.67, eating law 72.14, the difference between the two groups was significant (P0.05); The sleep time of the two groups was comparable, but there was no significant difference (P0.05). See table 3 for details. In the dietary survey, there were significant differences between the experimental group and the control group (P0.05): fried food, smoked and cured food, spicy food, strong tea coffee, Milk. 1.3 anxiety (100.00%), depression (100.00%), interpersonal sensitivity (80.00%), obsessive-compulsive disorder (50.00%), hostility (40.00%) were found in 9 factors of SCL-90 鈮，

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