轻微肝性脑病患者默认模式网络功能连接研究
发布时间：2018-12-31 13:22
【摘要】：目的采用静息态功能磁共振成像(rs-fMRI)研究轻微肝性脑病患者默认网络(DMN)脑区功能连接的改变情况。方法本研究共纳入73例肝硬化患者和73名匹配的健康对照者进行rs-fMRI扫描,采用DPARSF软件分析得到DMN相关脑区功能连接的变化情况,并使用方差分析比较各组之间差异;使用皮尔森相关分析DMN中脑区功能连接改变和神经心理功能测试结果之间的联系,ROC分析评估可靠性。结果与HC组相比,肝硬化患者DMN中额前内侧回(MPFC),后扣带回/楔前叶(PCC/PCUN),左侧颞极(TP)以及双侧海马旁回(PHG)DMN连接下降,而与non-HE患者相比,MHE组患者在MPFC,PCC/PCUN,以及右侧PHG脑区间的功能连接降低。其中MPFC出现改变的有效性最高(敏感度81.5%,特异度70.4%)。结论肝硬化患者从non-HE发展为MHE的过程中,DMN部分脑区的功能连接减低,这为轻微肝性脑病的诊断提供了一种新的思路。
[Abstract]:Objective to study the changes of functional connections in the default network of (DMN) in patients with mild hepatic encephalopathy by resting functional magnetic resonance imaging (rs-fMRI). Methods 73 patients with liver cirrhosis and 73 matched healthy controls were included in this study. The changes of functional connections in DMN related brain regions were analyzed by DPARSF software and the differences between the groups were compared by ANOVA. Pearson correlation was used to analyze the relationship between the changes of functional connections in the midbrain area of DMN and the results of neuropsychological function tests. ROC analysis was used to evaluate the reliability. Results compared with the HC group, the posterior cingulate gyrus (PCC/PCUN), the left temporal pole (TP) and the (PHG) DMN junction in the bilateral parahippocampal gyrus were decreased in DMN patients with DMN, but compared with those in non-HE patients. The functional junctions in MPFC,PCC/PCUN, and right PHG were decreased in MHE group. Changes in MPFC were most effective (sensitivity 81.5%, specificity 70.4%). Conclusion in the process of developing from non-HE to MHE, the functional junctions of some areas of DMN in patients with liver cirrhosis are decreased, which provides a new way for the diagnosis of mild hepatic encephalopathy.
【作者单位】： 重庆医科大学附属第二医院影像科
【分类号】：R445.2;R575.3
[Abstract]:Objective to study the changes of functional connections in the default network of (DMN) in patients with mild hepatic encephalopathy by resting functional magnetic resonance imaging (rs-fMRI). Methods 73 patients with liver cirrhosis and 73 matched healthy controls were included in this study. The changes of functional connections in DMN related brain regions were analyzed by DPARSF software and the differences between the groups were compared by ANOVA. Pearson correlation was used to analyze the relationship between the changes of functional connections in the midbrain area of DMN and the results of neuropsychological function tests. ROC analysis was used to evaluate the reliability. Results compared with the HC group, the posterior cingulate gyrus (PCC/PCUN), the left temporal pole (TP) and the (PHG) DMN junction in the bilateral parahippocampal gyrus were decreased in DMN patients with DMN, but compared with those in non-HE patients. The functional junctions in MPFC,PCC/PCUN, and right PHG were decreased in MHE group. Changes in MPFC were most effective (sensitivity 81.5%, specificity 70.4%). Conclusion in the process of developing from non-HE to MHE, the functional junctions of some areas of DMN in patients with liver cirrhosis are decreased, which provides a new way for the diagnosis of mild hepatic encephalopathy.
【作者单位】： 重庆医科大学附属第二医院影像科
【分类号】：R445.2;R575.3
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