枳术宽中胶囊联合凝结芽孢杆菌治疗功能性便秘的临床观察

发布时间：2019-01-21 13:19

【摘要】：目的通过临床观察，论证枳术宽中胶囊联合凝结芽孢杆菌治疗功能性便秘的实用性、科学性，并证明该种联合治疗是治疗便秘的有效方法。方法收集2012年5月份到2013年5月份，就诊于山西省人民医院消化科门诊并符合功能性便秘诊断标准的病人共60例，，随机分为对照组1、对照组2、治疗组，每组各20例。对照组1给予枳术宽中胶囊口服，对照组2给予凝结芽孢杆菌活菌片口服，治疗组给予枳术宽中胶囊和凝结芽孢杆菌活菌片口服。在治疗前及治疗一个月后，分别对3组患者的中医临床症状积分进行统计，观察分析三组的疗效。结果三组患者治疗结束后，枳术宽中胶囊组（对照组1）治愈1例（5%），显效6例（30%），有效8例（40%），无效5例（25%），总显效率35%，总有效率75%；凝结芽孢杆菌组（对照组2）治愈2例（10%），显效6例（30%），有效9例（45%），无效3例（15%），总显效率40%，总有效率85%；枳术宽中胶囊联合凝结芽孢杆菌组（治疗组）治愈5例（25%），显效10例（50%），有效4例（20%），无效1例（5%），总显效率75%，总有效率95%。经统计学分析，三组治疗结果在总有效率方面差异无统计学意义（P0.05），但在显效率方面差异有统计学意义（P0.05），说明治疗组疗效优于对照组1、2；治疗结束后对三组患者中医症状积分进行比较，差异具有统计学意义（P0.05），说明枳术宽中胶囊联合凝结芽孢杆菌对功能性便秘的症状改善情况优于两种药物的单独治疗情况。结论枳术宽中胶囊联合凝结芽孢杆菌治疗功能性便秘优于传统的口服药治疗，值得临床推广。
[Abstract]:Objective to demonstrate the practicability and scientificity of Zhizhukanzhong capsule combined with Bacillus coagulans in the treatment of functional constipation, and to prove that the combined therapy is an effective method for the treatment of constipation. Methods from May 2012 to May 2013, 60 patients who met the diagnostic criteria of functional constipation were randomly divided into control group (n = 20), control group (n = 2) and treatment group (n = 20). Control group 1 was administered with Zhizhukanzhong capsule, control group 2 with Bacillus coagulans active bacteria tablets, treatment group with trifoliate orange Kuanzhuanzhong capsule and Bacillus coagulans active bacteria tablet. Before and one month after treatment, the clinical symptom scores of three groups of patients were statistically analyzed and the curative effects of the three groups were observed and analyzed. Results after treatment, 1 case (5%) was cured, 6 cases (30%) were significantly effective, 8 cases (40%) were effective, 5 cases (25%) were ineffective, the total effective rate was 35% and the total effective rate was 75% in the Zhizhoukanzhong capsule group (control group 1). In the control group, 2 cases (10%) were cured, 6 cases (30%) were cured, 9 cases (45%) were effective, 3 cases (15%) were ineffective, the total effective rate was 40% and the total effective rate was 85%. In the treatment group, 5 cases (25%) were cured, 10 cases (50%) were effective, 4 cases (20%) were effective, 1 case (5%) was ineffective, the total effective rate was 7575% and the total effective rate was 95%. By statistical analysis, the results of the three groups in the total effective rate difference was not statistically significant (P0.05), but there was significant difference in the effective rate (P0.05), indicating that the therapeutic effect of the treatment group is better than that of the control group (1 / 2); After the treatment, the scores of TCM symptoms in the three groups were compared and the difference was statistically significant (P0.05). The results showed that the symptom improvement of Zhizhushuanzhong capsule combined with Bacillus coagulans on functional constipation was better than that of two drugs alone. Conclusion Zhizhushuanzhong capsule combined with Bacillus coagulans in the treatment of functional constipation is better than the traditional oral drug therapy, and it is worth popularizing.
【学位授予单位】：山西中医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574.62

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