血清Ghrelin及胸腔积液变化对急性胰腺炎患者病情的评估价值

发布时间：2019-01-21 15:22

【摘要】：目的探究血清Ghrelin及胸腔积液变化对急性胰腺炎患者病情的评估价值。方法选取2011年2月至2014年2月该院收治的急性胰腺炎患者80例,根据患者病情的轻重将患者分为轻症组(31例)和重症组(49例),所有患者均抽取入院时、入院后48h和出院当日清晨空腹情况下的静脉血,检测患者C反应蛋白(CRP)、白细胞(WBC)、降钙素原(PCT)水平;采用酶联免疫吸附法测定患者血清Ghrelin的水平;拍胸片确诊患者胸腔积液。结果与轻症组比较,重症组患者血清Ghrelin、CRP水平、APACHE评分、CT评分、Ranson评分较高,住院天数较长(P0.01);CRP、胸腔积液、血清Ghrelin、血清Ghrelin联合胸腔积液的曲线下面积分别为0.708 3、0.749 6、0.852 4、0.910 8。血清Ghrelin联合胸腔积液对急性胰腺炎患者病情的评估价值最高。CRP敏感性为93.6%、特异性为69.4%、准确性为73.7%;胸腔积液敏感性为75.2%、特异性为88.7%、准确性为76.8%;Ghrelin敏感性为86.9%、特异性为88.2%、准确性为85.3%;血清Ghrelin联合胸腔积液敏感性为90.1%、特异性为92.6%、准确性为91.4%。结论血清Ghrelin联合胸腔积液变化对急性胰腺炎患者病情评估的敏感度、特异性和准确性较高,具有较高的临床价值。
[Abstract]:Objective To investigate the value of serum Ghrelin and the changes of pleural effusions in patients with acute pancreatitis. Methods 80 patients with acute pancreatitis admitted to the hospital from February 2011 to February 2014 were selected. The patients were divided into mild group (31 cases) and severe group (49 cases) according to the severity of the condition of the patient, and all the patients were admitted to the hospital, and the venous blood in the early morning of the discharge was 48h and the early morning of the discharge. The levels of C-reactive protein (CRP), white blood cell (WBC) and procalcitonin (PCT) in patients were detected, and the level of Ghrelin in patients was determined by enzyme-linked immunosorbent assay (ELISA). Results The serum Ghrelin, CRP level, APACHE score, CT score and Ranson score of the severe group were higher and the number of hospital stay was longer (P0.01). The area of CRP, pleural effusion, serum Ghrelin, and the serum Ghrelin combined with the pleural effusion were 0.708 3, 0.749 6, 0.852 4, 0.910 8, respectively. The value of serum Ghrelin combined with pleural effusion was the highest in the patients with acute pancreatitis. The sensitivity of CRP was 93.6%, the specificity was 69.4%, the accuracy was 73.7%, the sensitivity of pleural effusion was 75.2%, the specificity was 85.7%, the accuracy was 76.8%, the sensitivity of Ghrelin was 86.9%, the specificity was 81.2%, the accuracy was 85.3%, and the sensitivity of the serum Ghrelin combined with the pleural effusion was 90.1%. The specificity was 92.6% and the accuracy was 91.4%. Conclusion The sensitivity, specificity and accuracy of serum Ghrelin combined with pleural effusion in patients with acute pancreatitis have high clinical value.
【作者单位】：安徽医科大学第二附属医院急诊外科;
【分类号】：R576

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