急性炎症性肠炎的病原菌分布与耐药性分析

发布时间：2019-02-14 07:19

【摘要】：目的探讨急性炎症性肠炎患者病原菌分布及其耐药性,旨在为临床合理用药提供依据。方法选取2010年12月-2013年12月收治的90例急性肠炎患者为研究对象,收集患者粪便标本进行病原菌检测及药敏试验;菌株鉴定按《全国临床检验操作规程》进行操作,药敏试验采用K-B纸片法,采用SPSS17.0和Excel软件进行统计分析。结果共分离出病原菌103株,前5位病原菌依次为志贺菌属、沙门菌属、副溶血弧菌、艰难梭菌、大肠埃希菌,分别占52.43%、21.36%、13.59%、6.80%、4.85%;志贺菌属、沙门菌属、副溶血弧菌对头孢哌酮/舒巴坦、阿莫西林/克拉维酸、阿米卡星、环丙沙星、庆大霉素高度敏感,耐药率10.00%,沙门菌属对庆大霉素敏感率达100.00%,副溶血弧菌对头孢哌酮/舒巴坦及环丙沙星敏感率达100.00%,但对头孢曲松、头孢他啶、氨苄西林、头孢唑林、头孢拉定等高度耐药,耐药率均70.00%。结论急性炎症性肠炎患者的病原菌分布较广,耐药性逐年增加,临床应加强病原菌检测及耐药性分析,有针对性的选择抗菌药物,减少抗菌药物的滥用。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogenic bacteria in patients with acute inflammatory enteritis. Methods from December 2010 to December 2013, 90 patients with acute enteritis were selected as the study subjects, and stool samples were collected for pathogen detection and drug sensitivity test. The strain identification was performed according to the National procedure for Clinical examination. The drug sensitivity test was performed by K-B disk method and SPSS17.0 and Excel software. Results 103 strains of pathogenic bacteria were isolated, and the first five pathogens were Shigella, Salmonella, Vibrio parahaemolyticus, Clostridium difficulty, Escherichia coli, which accounted for 52.431.360.13.596.800.4.85. Shigella, Salmonella, Vibrio parahaemolyticus were highly sensitive to cefoperazone / sulbactam, amoxicillin / clavulanic acid, amikacin, ciprofloxacin, gentamicin, and the drug resistance rate was 10.00%. The sensitivity of Salmonella to gentamicin was 100.00m, Vibrio parahaemolyticus to cefoperazone / sulbactam and ciprofloxacin 100.00cm, but to ceftriaxone, ceftazidime, ampicillin, cefazolin, Cefradine was highly resistant, and the drug resistance rate was 70.005%. Conclusion the distribution of pathogenic bacteria in patients with acute inflammatory enteritis is wide and the drug resistance is increasing year by year. It is necessary to strengthen the detection of pathogenic bacteria and analysis of drug resistance in clinic so as to select antimicrobial agents and reduce the abuse of antimicrobial agents.
【作者单位】：浙江省新华医院消化内科;
【基金】：浙江省中医药管理局基金资助项目(20132B065)
【分类号】：R574

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