幽门螺杆菌感染与老年高血压患者新发心脑血管疾病的相关性研究

发布时间：2019-02-15 01:26

【摘要】：目的探讨幽门螺旋杆菌(Hp)感染与老年高血压患者新发心脑血管疾病的相关性影响,以期为老年高血压患者新发心脑血管事件寻找诱因。方法选取医院2011年1月-2012年1月内科及消化内科门诊收治高血压老年患者2 534例,所有患者均确诊为Hp感染,随机单盲取法分为观察组与对照组各1 267例,对照组给予常规降压、对症治疗,观察组在对照组基础上给予抗Hp治疗,治疗1周后剔除Hp阳性患者;比较两组患者临床指标。结果观察组治疗1年后、末次随访血脂指标总胆固醇、甘油三酯、低密度脂蛋白均低于治疗前及对照组同期(P0.05);随访1年间,观察组心脑血管事件发生率3.17%低于对照组8.37%(P0.05)。结论 Hp感染对老年高血压患者新发心脑血管事件具有促进作用,可使血脂、炎性因子水平增高,促进动脉粥样硬化进程,增加新发生心脑血管事件发生。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (Hp) infection and new cardiovascular and cerebrovascular diseases in elderly patients with hypertension. Methods from January 2011 to January 2012, 2 534 elderly patients with hypertension were selected. All the patients were diagnosed with Hp infection. The patients were randomly divided into observation group and control group with 1 267 cases each. The control group was treated with conventional hypotension and symptomatic treatment, while the observation group was treated with anti Hp on the basis of the control group. After 1 week of treatment, Hp positive patients were excluded. The clinical indexes were compared between the two groups. Results after one year of treatment, the total cholesterol, triglyceride and low density lipoprotein in the observation group were lower than those in the control group and before treatment (P0.05). The incidence of cardiovascular and cerebrovascular events in the observation group was lower than that in the control group (3.17% vs 8.37%, P0.05). Conclusion Hp infection can promote the occurrence of new cardiovascular and cerebrovascular events in elderly patients with hypertension, increase the level of blood lipids and inflammatory factors, promote the progression of atherosclerosis, and increase the occurrence of new cardiovascular and cerebrovascular events.
【作者单位】：济宁医学院附属医院兖州院区心内科;兖矿集团有限公司总医院呼吸内科;
【基金】：山东省科学技术发展基金资助项目(201239689KF)
【分类号】：R544.1;R57

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