异甘草酸镁注射液对比4种常用药物治疗药物性肝损害有效性与安全性的系统评价

发布时间：2019-02-15 06:47

【摘要】：目的:系统评价异甘草酸镁注射液对比4种常用药物治疗药物性肝损害的有效性与安全性,以为临床治疗提供循证参考。方法:计算机检索Pub Med、EMBase、Cochrane图书馆、中国生物医学文献数据库、相关期刊论文、万方数据库和中国科技期刊数据库,纳入异甘草酸镁注射液对比其他药物治疗药物性肝损害的随机对照试验(RCT),筛查文献、提取资料并进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:最终纳入13项RCT,合计1 093例患者。Meta分析结果显示,异甘草酸镁组患者有效率显著高于硫普罗宁组[RD=0.29,95%CI(0.17,0.42),P0.001]和甘草酸二胺组[RD=0.07,95%CI(0.01,0.12),P=0.02],与谷胱甘肽组、复方甘草酸单胺组比较差异无统计学意义;异甘草酸镁组患者不良反应发生率显著低于甘草酸二铵组[RD=-0.07,95%CI(-0.11,-0.03),P0.001]和复方甘草酸单胺组[RD=-0.21,95%CI(-0.38,-0.04),P=0.02],与硫普罗宁组、谷胱甘肽组比较差异无统计学意义。结论:异甘草酸镁注射液治疗药物性肝损害的疗效与安全性均优于4种常用保肝药物。受纳入研究方法学质量的限制,该结论有待设计严格的RCT进一步验证。
[Abstract]:Objective: to evaluate the efficacy and safety of magnesium isoglycyrrhizinate injection in the treatment of drug-induced liver injury. Methods: Pub Med,EMBase,Cochrane Library, Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Wanfang Database and Chinese Sci-tech Journal Database were searched by computer. A randomized controlled trial (RCT),) screening literature of magnesium isoglycyrrhizinate injection in comparison with other drugs in the treatment of drug-induced liver damage was included. After extracting the data and evaluating the quality, the Meta analysis was carried out by Rev Man 5.3 statistical software. Results: a total of 1 093 patients with 13 items of RCT, were included. The results of Meta analysis showed that the effective rate of magnesium isoglycyrrhizinate group was significantly higher than that of tiopronin group [RD=0.29,95%CI (0.17 ~ 0.42)]. Compared with glutathione group and compound glycyrrhizic acid monoamine group, there was no significant difference between P0. 001 and glycyrrhizic acid diamine group [RD=0.07,95%CI (0. 01, 0. 12), P0. 02]. The incidence of adverse reactions in magnesium isoglycyrrhizinate group was significantly lower than that in diammonium glycyrrhizinate group [RD=-0.07,95%CI (-0.11) -0.03, P0.001] and compound glycyrrhizic acid monoamine group [RD=-0.21,95%CI (-0.38), P 0.001]. There was no significant difference between the two groups in comparison with Tiopronin group and glutathione group. Conclusion: the efficacy and safety of magnesium isoglycyrrhizinate injection in the treatment of drug-induced liver injury is superior to that of four commonly used hepatoprotective drugs. Limited by the quality of methodology included in the study, this conclusion needs to be further verified by a strictly designed RCT.
【作者单位】：华北理工大学附属医院重症医学科;
【分类号】：R575

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