舒肝解郁胶囊联合奥美拉唑对功能性消化不良患者生活质量的影响

发布时间：2019-02-16 21:25

【摘要】：目的:观察舒肝解郁胶囊与奥美拉唑在功能性消化不良的应用疗效和生活质量影响。方法:功能性消化不良患者140例。分为治疗组70例(舒肝解郁+奥美拉唑)和对照组70例(奥美拉唑),治疗4周后进行疗效评估,治疗前后分别进行健康相关生活质量评分(SF-36)和尼平消化不良指数(NDI)的评分。结果:两组最终完成研究各59例,治疗过程中均无明显的药物不良反应。治疗组的临床总有效率(96.61%)明显高于对照组(71.19%);治疗组治疗后的SF-36和NDLQI评分[(85.34±21.34)分,(78.61±19.66)分]明显高于治疗前[(60.90±15.23)分,(54.95±13.74)分]及对照组治疗后[(74.36±18.59)分,(65.85±16.47)分];治疗组治疗后的NDI评分[(16.69±4.18)分]明显低于治疗前[(49.34±12.34)分]及对照组治疗后[(23.05±5.77)分];治疗组治疗后的焦虑、抑郁及压力感知评分[(5.02±1.26)分,(4.27±1.07)分,(12.17±3.05)分]明显低于治疗前[(7.24±1.81)分,(6.46±1.62)分,(15.62±3.91)分]及对照组治疗后[(6.77±1.70)分,(5.99±1.50)分,(14.72±3.68)分],差异均具有统计学意义(P0.05)。结论:舒肝解郁胶囊联合奥美拉唑对功能性消化不良有较好的临床疗效,而且能明显改善患者的心理状态及生活质量。
[Abstract]:Objective: to observe the effect of Shugan Jieyu capsule and omeprazole on functional dyspepsia. Methods: 140 patients with functional dyspepsia. The patients were divided into treatment group (70 cases) and control group (70 cases). Health-related quality of life (SF-36) and nippin dyspepsia index (NDI) were evaluated before and after treatment. Results: there were 59 cases in each group, and there was no obvious adverse drug reaction in the course of treatment. The total effective rate of the treatment group (96.61%) was significantly higher than that of the control group (71.19%). The SF-36 and NDLQI scores in the treatment group [(85.34 卤21.34), (78.61 卤19.66)] were significantly higher than those before treatment [(60.90 卤15.23), (54.95 卤13.74)] and after treatment in the control group [(74.36 卤18.59)]. (65.85 卤16.47); The NDI score after treatment in the treatment group [(16.69 卤4.18)] was significantly lower than that before the treatment [(49.34 卤12.34) points] and in the control group [(23.05 卤5.77) points]. The scores of anxiety, depression and stress perception in the treatment group [(5.02 卤1.26), (4.27 卤1.07), (12.17 卤3.05)] were significantly lower than those before treatment [(7.24 卤1.81), (6.46 卤1.62)]. (15.62 卤3.91) and control group [(6.77 卤1.70), (5.99 卤1.50), (14.72 卤3.68)], the difference was statistically significant (P0.05). Conclusion: Shugan Jieyu capsule combined with omeprazole has better clinical effect on functional dyspepsia and can obviously improve the psychological state and quality of life of the patients.
【作者单位】：嘉兴市第二医院消化内科;
【分类号】：R57

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