三联疗法治疗幽门螺杆菌感染胃溃疡疗效比较

发布时间：2019-06-15 13:05

【摘要】：目的探讨雷贝拉唑、兰索拉唑及奥美拉唑三联疗法治疗幽门螺杆菌(Hp)感染消化性胃溃疡临床疗效及安全性,为临床治疗Hp感染消化性胃溃疡提供参考。方法选择2010年3月-2014年6月医院收治的128例Hp感染性胃溃疡患者为研究对象,将患者随机分为A组42例、B组43例与C组43例,A组患者给予奥美拉唑+阿莫西林+克拉霉素,B组患者给予兰索拉唑+阿莫西林+克拉霉素,C组患者给予雷贝拉唑+阿莫西林+克拉霉素,连续治疗4周,评价患者症状改善及治疗后溃疡愈合及Hp根除情况。结果治疗后总有效率A组为76.19%、B组为74.42%、C组为81.39%,3组比较差异无统计学意义;3组Hp根除率比较差异无统计学意义;3组临床症状与胃溃疡面直径均显著减少(P0.05);3组IL-6、IL-8水平均显著低于治疗前(P0.05);治疗后IL-6、IL-8水平3组比较均无显著差异;不良反应发生率A组为9.52%、B组为11.63%、C组为6.98%,3组比较差异无统计学意义。结论雷贝拉唑、兰索拉唑及奥美拉唑三联疗法均可根除Hp,促进胃溃疡愈合,缓解消化性胃溃疡临床症状,雷贝拉唑三联疗法在促进胃溃疡愈合及改善临床症状优于兰索拉唑及奥美拉唑。
[Abstract]:Objective to investigate the clinical efficacy and safety of rabeprazole, lansoprazole and omeprazole in the treatment of peptic gastric ulcer infected with HP (Hp), and to provide reference for clinical treatment of peptic gastric ulcer infected with Hp. Methods from March 2010 to June 2014, 128 patients with Hp infectious gastric ulcer were randomly divided into group A (n = 42), group B (n = 43) and group C (n = 43). Group A was treated with omeprazole amoxicillin clarithromycin, group B was treated with lansoprazole amoxicillin clarithromycin, and group C was treated with rabeprazole amoxicillin clarithromycin for 4 weeks. To evaluate the improvement of symptoms, ulcer healing and Hp eradication after treatment. Results after treatment, the total effective rate was 76.19% in group A, 74.42% in group B and 81.39% in group C, and there was no significant difference in Hp eradication rate among the three groups. The clinical symptoms and the diameter of gastric ulcer surface in the three groups were significantly decreased (P 0.05), and the IL-6,IL-8 levels in the three groups were significantly lower than those before treatment (P 0.05). There was no significant difference in the level of IL-6,IL-8 among the three groups after treatment, and the incidence of adverse reactions was 9.52% in group A, 11.63% in group B and 6.98% in group C. there was no significant difference among the three groups. Conclusion the triple therapy of rabeprazole, lansoprazole and omeprazole can eradicate Hp, and promote the healing of gastric ulcer and alleviate the clinical symptoms of peptic gastric ulcer. Rabeprazole triple therapy is superior to lansoprazole and omeprazole in promoting the healing of gastric ulcer and improving the clinical symptoms.
【作者单位】：解放军第63870部队医院消化内科;解放军第323部队医院消化内科;第四军医大学唐都医院消化内科;
【基金】：国家自然科学基金杰出青年基金资助项目(30225039)
【分类号】：R573.1

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