高分辨率食管测压在贲门失弛缓症经口内镜下肌切开术效果评价中的价值
发布时间：2019-06-21 06:36
【摘要】：目的观察经口内镜下肌切开术(POEM)治疗贲门失弛缓症(AC)前后食管压力的变化,并探讨食管高分辨率测压(HRM)在评价POEM疗效中的价值。方法收集2015年8月-2016年11月在郑州大学第一附属医院确诊为AC并接受POEM治疗者38例,分别在术前、术后1周和术后1个月,采用食管HRM检测食管上扩约肌静息压(UESP)、食管下括约肌静息压(LESP)和食管下括约肌4秒完整松弛压(4s IRP),评价疗效进行回顾性分析。结果38例AC患者的POEM均顺利完成。患者术后1周、术后1个月的食管UESP分别为(45.34±26.52)和(41.27±20.09)mm Hg,与术前(49.58±26.47)mm Hg相比差异无统计学意义(t_(术后1周/术前)=0.49,t_(术后1个月/术前)=1.09,均P0.05);术后1周和术后1个月的食管LESP、4s IRP与术前相比差异均具有统计学意义(LESP:t_(术后1周/术前)=3.86,t_(术后1个月/术前)=4.86;4s IRP:t_(术后1周/术前)=4.85,t_(术后1个月/术前)=7.14;均P0.05);术后1周与术后1个月相比,UESP、LESP、4s IRP变化差异均无统计学意义(UESP:t_(术后1周/术后1个月)=0.53,LESP:t_(术后1周/术后1个月)=1.86;4s IRP:t_(术后1周/术后1个月)=1.84,均P0.05)。结论POEM后食管LESP明显降低,吞咽困难改善,食管HRM对于评价AC经POEM术的疗效有临床意义。
[Abstract]:Objective to observe the changes of esophageal pressure before and after endoscopic myotomy (POEM) in the treatment of achalasia of cardia (AC), and to explore the value of high resolution esophageal manometry (HRM) in evaluating the efficacy of POEM. Methods 38 patients with AC diagnosed and treated with POEM in the first affiliated Hospital of Zhengzhou University from August 2015 to November 2016 were collected. Esophageal HRM was used to detect the resting pressure of (UESP), lower esophageal sphincter and 4 seconds complete relaxation pressure of lower esophageal sphincter before, 1 week and 1 month after operation, respectively. The efficacy of (LESP) and 4 seconds complete relaxation pressure of inferior esophageal sphincter was analyzed retrospectively. Results POEM was successfully completed in 38 patients with AC. The esophageal UESP of the patients 1 week after operation and 1 month after operation were (45.34 卤26.52) and (41.27 卤20.09) mm Hg,), respectively, which were not significantly different from those before operation (49.58 卤26.47) mm Hg) (t _ (1 week / before operation) = 0.49, t _ (1 month / before operation) = 1.09, P 0.05). The esophageal LESP,4s IRP at 1 week and 1 month after operation was significantly different from that before operation (LESP:t_ (1 week / pre-operation) = 3.86, t _ (1 month / pre-operation) = 4.86 鈮，
本文编号：2503870
[Abstract]:Objective to observe the changes of esophageal pressure before and after endoscopic myotomy (POEM) in the treatment of achalasia of cardia (AC), and to explore the value of high resolution esophageal manometry (HRM) in evaluating the efficacy of POEM. Methods 38 patients with AC diagnosed and treated with POEM in the first affiliated Hospital of Zhengzhou University from August 2015 to November 2016 were collected. Esophageal HRM was used to detect the resting pressure of (UESP), lower esophageal sphincter and 4 seconds complete relaxation pressure of lower esophageal sphincter before, 1 week and 1 month after operation, respectively. The efficacy of (LESP) and 4 seconds complete relaxation pressure of inferior esophageal sphincter was analyzed retrospectively. Results POEM was successfully completed in 38 patients with AC. The esophageal UESP of the patients 1 week after operation and 1 month after operation were (45.34 卤26.52) and (41.27 卤20.09) mm Hg,), respectively, which were not significantly different from those before operation (49.58 卤26.47) mm Hg) (t _ (1 week / before operation) = 0.49, t _ (1 month / before operation) = 1.09, P 0.05). The esophageal LESP,4s IRP at 1 week and 1 month after operation was significantly different from that before operation (LESP:t_ (1 week / pre-operation) = 3.86, t _ (1 month / pre-operation) = 4.86 鈮，
本文编号：2503870
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