梗阻性黄疸患者血清胱抑素C的表达及其经皮肝胆管穿刺引流术后的变化

发布时间：2019-06-26 22:05

【摘要】：目的探讨梗阻性黄疸患者血清胱抑素C(Cys C)的表达及经皮肝胆管穿刺引流术(PTCD)治疗前后的变化。方法收集72例梗阻性黄疸患者,行磁共振胰胆管造影(MRCP)检查明确梗阻后行PTCD。设正常组、梗阻性黄疸组(PTCD组),测定血清Cys C、肌酐(CREA)、总胆红素(TBIL)水平,比较各组指标的差异。结果 PTCD组术前、PTCD组术后、正常组间TBIL、Cys C水平比较差异均有统计学意义,且PTCD组术前、术后均高于正常组(P0.001);PTCD组术前、PTCD组术后、正常组间CREA水平无明显差异(P0.05)。Cys C与CREA、TBIL均呈正相关性(r=0.320、0.265,P均0.001)。治疗后Cys C和TBIL较治疗前明显下降(P0.01)。PTCD组术前Cys C的异常率为58.33%(42/72),CREA的异常率为11.11%(8/72);PTCD组术后Cys C的异常率为19.44%(14/72),CREA的异常率为8.33%(6/72);正常组Cys C、CREA的异常率为0。结论 Cys C既可反应梗阻性黄疸高胆红素血症毒性,也可作为梗阻性黄疸并发肾功能异常的早期敏感指标。
[Abstract]:Objective to investigate the expression of serum cystine C (Cys C) in patients with obstructive jaundice and the changes before and after (PTCD) treatment. Methods 72 patients with obstructive jaundice were examined by magnetic resonance cholangiopancreatography (MRCP). PTCD. was performed after obstruction. Normal group, obstructive jaundice group (PTCD group), serum Cys C, creatine (CREA), total bilirubin (TBIL) levels were measured, and the differences of each group were compared. Results there was significant difference in the level of TBIL,Cys C between PTCD group and PTCD group before and after operation, and the level of TBIL,Cys C in PTCD group was significantly higher than that in normal group before and after operation (P0.001); PTCD group, PTCD group). There was no significant difference in CREA level between normal group before operation and PTCD group (P < 0.05). There was a positive correlation between). Cys C and CREA,TBIL (r 鈮，

本文编号：2506533