二甲双胍治疗2型糖尿病合并非酒精性脂肪肝病的临床观察

发布时间：2019-07-23 20:05

【摘要】：目的:观察二甲双胍治疗2型糖尿病(T2DM)合并非酒精性脂肪肝病(NAFLD)的疗效和安全性。方法:106例T2DM合并NAFLD患者随机均分为对照组和观察组。对照组患者接受T2DM合并NAFLD的健康教育,并给予生活干预治疗(糖尿病饮食、运动治疗);观察组患者在对照组治疗的基础上给予二甲双胍片0.5 g,口服,每日3次。两组患者疗程均为12周。观察两组患者的临床疗效,治疗前后肝脏脂肪含量、体质量指数(BMI)、空腹血糖(FPG)、稳态胰岛素评价指数(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(Hb A1c)及不良反应发生情况。结果:治疗后,两组患者肝脏脂肪含量、上述指标(除对照组HOMA-IR外)均显著优于同组治疗前,且观察组优于对照组,差异均有统计学意义(P0.05)。观察组患者总有效率显著高于对照组,差异有统计学意义(P0.05)。两组患者治疗期间均未见明显不良反应发生。结论 :在常规治疗的基础上,二甲双胍治疗T2DM合并NAFLD的疗效和安全性均较好。
[Abstract]:Objective: to observe the efficacy and safety of metformin in the treatment of type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods: 106 patients with T2DM complicated with NAFLD were randomly divided into control group and observation group. The patients in the control group received health education of T2DM combined with NAFLD and were given life intervention therapy (diabetic diet, exercise therapy), while the patients in the observation group were given metformin tablets 0.5g, oral three times a day, on the basis of treatment in the control group. The course of treatment in both groups was 12 weeks. The clinical efficacy, liver fat content, body mass index (BMI), fasting blood glucose (FPG), steady insulin evaluation index (HOMA-IR), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin (Hb A1c) and adverse reactions were observed before and after treatment. Results: after treatment, the liver fat content of the two groups (except the control group HOMA-IR) was significantly better than that of the same group before treatment, and the observation group was better than the control group, the difference was statistically significant (P 0.05). The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P 0.05). There were no obvious adverse reactions during treatment in both groups. Conclusion: metformin is effective and safe in the treatment of T2DM complicated with NAFLD on the basis of routine treatment.
【作者单位】：解放军第117医院内分泌科;
【分类号】：R587.1;R575.5

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