达立通颗粒联合奥美拉唑治疗胃食管反流的临床观察

发布时间：2019-08-15 15:47

【摘要】：目的:观察达立通颗粒联合奥美拉唑治疗胃食管反流的临床疗效和安全性。方法:将104例胃食管反流患者随机均分为对照组和观察组。对照组患者给予多潘立酮片1片,饭前30 min口服,tid+奥美拉唑肠溶胶囊1粒,口服,bid;观察组患者在对照组治疗的基础上给予达立通颗粒1袋,口服,tid。两组患者疗程均为30 d。观察两组患者临床疗效,治疗前后临床症状评分、食管黏膜病变分级情况及不良反应。结果:观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P0.05)。治疗前两组患者临床症状评分、食管黏膜病变分级情况比较,差异均无统计学意义(P0.05)。治疗后两组患者临床症状评分均显著低于同组治疗前,且观察组低于对照组;食管黏膜病变N、M级例数均显著多于同组治疗前,且观察组多于对照组;A、B、C、D级例数均显著少于同组治疗前,且观察组A、B级例数少于对照组,差异均有统计学意义(P0.05)。观察组患者不良反应发生率显著低于对照组,差异有统计学意义(P0.05)。结论:达立通颗粒联合奥美拉唑治疗胃食管反流较奥美拉唑疗效更显著,且安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of Dalitong granule combined with omeprazole in the treatment of gastroesophageal reflux. Methods: 104 patients with gastroesophageal reflux were randomly divided into control group and observation group. The patients in the control group were given domperidone tablets, 30 min before meals, tid omeprazole enteric-coated capsules, oral, and the patients in the bid; observation group were given 1 bag of Dalitong granules, oral, tid., on the basis of the treatment of the control group. The course of treatment in both groups was 30 days. The clinical efficacy, clinical symptom score, grade of esophageal mucosal lesions and adverse reactions were observed before and after treatment. Results: the total effective rate of the observation group was significantly higher than that of the control group, and there was significant difference between the two groups (P 0.05). Before treatment, there was no significant difference in clinical symptom score and esophageal mucosal lesion grade between the two groups (P 0.05). After treatment, the clinical symptom scores of the two groups were significantly lower than those of the same group before treatment, and the observation group was lower than the control group; the number of M grade cases of esophageal mucosal lesions was significantly higher than that of the same group before treatment, and that of the observation group was more than that of the control group; A, B, C and D cases of the same group were significantly less than those of the same group before treatment, and the number of grade B cases in the observation group was less than that of the control group, the difference was statistically significant (P 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P 0.05). Conclusion: Dalitong granule combined with omeprazole is more effective and safe in the treatment of gastroesophageal reflux than omeprazole.
【作者单位】：绍兴市柯桥区中医医院;浙江中医药大学附属第一医院;
【分类号】：R571

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