Reg IV在炎症性肠病的表达及其对病变活动度的预测作用

发布时间：2020-12-19 01:02

　　背景和目的炎症性肠病（inflammatory bowel disease, IBD）是一组病因未明的非特异性肠道炎症性疾病,包括溃疡性结肠炎（ulcerative colitis, UC）和克罗恩病（Crohn’s disease, CD）。近二十余年来,随着人们生活方式的变化和诊断水平的提高,国内炎症性肠病的发病率有逐年上升的趋势。疾病是处于活动期还是静止期直接关系到疾病的正确治疗。IBD临床表现复杂多变,诊断缺乏特异性的指标,而且常因对病情活动的判断不准确而延误治疗。目前临床评价IBD活动与否主要通过临床症状、实验室生化指标、内镜下的表现及病理等综合判断。其中C-反应蛋白（CRP）几乎全部由肝脏产生,短时间内（数小时）即可升高,而机体一旦恢复,CRP又迅速恢复正常（6～7d）。CRP可及时而敏感地反映炎症活动,是目前临床最为推崇的IBD活动性指标之一。另外,各国专家针对IBD制定出疾病活动指数（disease activity index）,对疾病的活动性进行量化处理,从而更客观准确地反映疾病的活动性,帮助临床医师作出正确的医疗决策。评价UC活动度常采用Southerland疾病... 

【文章来源】：南方医科大学广东省

【文章页数】：55 页

【学位级别】：硕士

【部分图文】：

一1在IBD病人及健康查体者肠粘膜中RegIV免疫组化染色

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