高氯酸铵对从业女工卵巢功能的影响

发布时间：2018-06-03 09:30

本文选题：高氯酸铵 + 职业暴露　；参考：《实用医学杂志》2015年04期

【摘要】：目的:探讨高氯酸铵对从业女工卵巢功能的影响。方法:采用病例-对照研究方法,选取密切接触高氯酸铵女工37例为暴露组,同一公司无高氯酸铵接触史者30例为对照组,收集两组人群的一般人口学特征、高氯酸铵暴露情况、月经情况等,采集清晨空腹静脉血,用放射免疫分析法检测血清性激素五项水平。结果:对高氯酸铵暴露组和对照组的FSH、PRL、E2、P和LH水平进行定量分析,未发现两组间血清FSH、E2、P、LH、PRL水平差异有统计学意义(P0.05)。将两组人群月经周期分为滤泡期、排卵期和黄体期,分析不同月经周期组间性激素水平,结果发现两组间各期激素水平差异无显著性(P0.05),但从中位数看,滤泡期暴露组FSH、LH及E2均高于对照组。采用非条件Logistic回归分析发现高氯酸铵暴露是影响从业女工FSH、LH及E2的危险因素。结论:高氯酸铵暴露对从业女工血清FSH、LH及E2水平有一定的影响,但其影响的程度尚有待进一步跟踪监测。
[Abstract]:Objective: to investigate the effect of ammonium perchlorate on ovarian function of female workers. Methods: a case-control study was conducted in which 37 female workers in close contact with ammonium perchlorate were selected as exposure group and 30 cases in the same company with no history of exposure to ammonium perchlorate as control group. The general demographic characteristics of the two groups were collected. The morning fasting venous blood was collected and the serum sex hormone levels were detected by radioimmunoassay. Results: the levels of serum FSHE2P and LH in the exposed group of ammonium perchlorate and the control group were quantitatively analyzed. No significant difference was found between the two groups. The menstrual cycle of the two groups was divided into follicular period, ovulation stage and luteal phase. The results showed that there was no significant difference in the levels of sex hormones between the two groups, but from the median, there was no significant difference in the levels of sex hormones between the two groups. The levels of FSH LH and E 2 in follicular exposure group were higher than those in control group. Non-conditional Logistic regression analysis showed that exposure to ammonium perchlorate was a risk factor affecting FSH LH and E 2 in female workers. Conclusion: exposure to ammonium perchlorate has a certain effect on serum FSHLH and E2 levels of female workers, but the extent of the effects remains to be further monitored.
【作者单位】：湖北航天医院妇产科;湖北航天医院检验科;湖北航天医院健康体检中心;
【基金】：航天科工集团公司医疗卫生科研项目(编号:2012-JKBZ-011)
【分类号】：R131

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