江苏省部分孕妇血清维生素D水平分析

发布时间：2018-06-13 06:31

  本文选题：孕妇 + -羟基维生素D　； 参考：《南京医科大学学报(自然科学版)》2017年07期

【摘要】：目的:分析江苏省部分孕期妇女不同季节血清维生素D水平,了解其维生素D营养状况。方法:于2013年1月—2015年12月间在江苏省8个地区不同医院的围产营养门诊采集18 478名健康孕妇的空腹血样,采用液相色谱-串联质谱(LC-MS/MS)法测量血清25-羟基维生素D3[25(OH)D3]和25-羟基维生素D2[25(OH)D2]的浓度。25(OH)D2和25(OH)D3总和为25-羟基维生素D[25(OH)D],以25(OH)D为体内维生素D水平的指标进行统计分析。结果:全部18 478名孕妇的血清25(OH)D浓度平均为(19.2±9.4)ng/mL,维生素D缺乏率[25(OH)D20 ng/mL]为59.7%,严重缺乏率[25(OH)D12 ng/mL]为24.9%,充足率[25(OH)D30 ng/mL]为13.7%。2013、2014、2015年孕妇的平均血清25(OH)D浓度分别为(17.3±8.5)、(18.2±9.0)、(20.5±9.7)ng/mL,其维生素D缺乏率分别为69.4%、63.6%、54.4%。不同年份孕妇25(OH)D水平的差异具有统计学意义(P0.01)。江苏省苏南、苏中、苏北地区的孕妇血清25(OH)D浓度平均分别为(19.2±9.5)、(19.6±9.0)、(18.4±8.7)ng/mL,维生素D缺乏率分别为60.0%、57.9%、62.8%,不同地区间孕妇25(OH)D水平的差异具有统计学意义(P0.01)。孕妇血清25(OH)D浓度与年龄呈正相关(r=0.8,P0.01)。孕妇维生素D的水平与检测血清25(OH)D浓度的季节有关,夏秋季高于春冬季,其血清25(OH)D浓度依次为(22.7±9.2)、(22.2±9.3)、(15.3±7.3)、(12.3±6.4)ng/mL。结论:孕妇维生素D缺乏率高,应加强对孕妇维生素D水平的监测,及时指导维生素D缺乏的孕妇合理补充维生素D。
[Abstract]:Objective: to analyze the serum vitamin D levels of some pregnant women in Jiangsu province and to understand their vitamin D nutritional status. Methods: from January 2013 to December 2015, the fasting blood samples of 18 478 healthy pregnant women were collected from perinatal nutrition outpatient clinics in 8 hospitals in Jiangsu Province. The concentrations of 25-hydroxy-vitamin D _ 3 and 25-hydroxyvitamin D _ 2 [25 OHH _ 2 D _ 2] were measured by liquid chromatography-tandem mass spectrometry (LC-MS / MS) method. The sum of 25 OHH D _ 2 and 25 OHH _ 2 D _ 3 were 25 hydroxyvitamin D [25OHD], and 25 OHH D was used as the index of vitamin D level in vivo. Results: the average serum concentration of 25 OHHN D in all 18 478 pregnant women was 19.2 卤9.4 ng / mL, the vitamin D deficiency rate was 59.7, the severe deficiency rate was 24.9, the filling rate was 13.7.2013ng/ mL, and the average serum concentration of 25OHHN in 2015 was 17.3 卤8.5ng-1 / mL, respectively. The vitamin D deficiency rate was 69.4ngmL, and the vitamin D deficiency rate was 69.4ngmL, respectively. The difference of OHH D level in pregnant women in different years was statistically significant (P 0.01). The average serum concentration of 25OHHU D was 19.2 卤9.5ng / mL in south Jiangsu, middle Jiangsu and northern Jiangsu, respectively. The vitamin D deficiency rate was 60.0% and 57.9% (P < 0.01), respectively. There was a positive correlation between the serum concentration of 25 OHH D and the age of pregnant women. The level of vitamin D in pregnant women was related to the season of detecting serum 25 OHH D, which was higher in summer and autumn than in spring and winter. The serum concentration of 25 OHH D was 22. 7 卤9. 2 卤9. 3 卤9. 3 卤9. 3 卤7. 3 卤6. 4 ng / mL. Conclusion: the rate of vitamin D deficiency in pregnant women is high. It is necessary to strengthen the monitoring of vitamin D level of pregnant women and guide the pregnant women with vitamin D deficiency to supplement vitamin D.
【作者单位】： 南京医科大学公共卫生学院儿少卫生与妇幼保健学系;南京医科大学公共卫生学院卫生检验系;
【基金】：江苏高校优势学科建设工程资助项目
【分类号】：R153.1
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本文编号：2013063