老年人肠道菌群特征与代谢和免疫机能相关性的探究

发布时间：2018-06-19 06:23

本文选题：老年人 + 乳酸杆菌　；参考：《营养学报》2017年03期

【摘要】：目的研究老年人肠道菌群的特征,探索肠道菌群与机体的生理生化、免疫机能的相关性。方法对成都地区170名中老年人进行生理、生化及免疫指标的检测的同时、采用荧光原位杂交方法(fluorescence in situ hybridization,FISH)对其粪便中的细菌总数、乳酸杆菌(Lactobacillus sp.)、拟杆菌(Bacteroides sp.)、梭菌属(Clostridium sp.)进行定量分析检测。结果 55~65岁乳酸杆菌浓度显著高于55岁及以下组(P0.05),拟杆菌和梭菌属浓度出现与乳酸杆菌相似的年龄趋势(P0.05);关联性分析显示年龄与总菌数(r=0.054,P0.05)、乳酸杆菌数量(r=0.150,P0.05)、拟杆菌数量(r=0.190,P0.05)、梭菌属数目(r=0.180,P0.05)均呈正相关关系;乳酸杆菌与空腹血糖的相关系数为0.241(P0.01);拟杆菌/梭菌比例与HDL-C显著正相关(r=0.200,P0.05);总菌数与Ig G正相关(r=0.177,P0.05)。结论肠道乳酸杆菌、拟杆菌、梭菌数量显著地增多可能是人体肠内细菌老化的重要的特征之一;肠道乳酸杆菌数也许可作为早期发现糖尿病高危人群的新指标;以提高肠道乳酸杆菌为目的中老年人群的益生菌的开发方向需要进一步研究。
[Abstract]:Objective to study the characteristics of intestinal flora in the elderly and to explore the relationship between intestinal flora and physiological, biochemical and immune function. Methods to detect physiological, biochemical and immunological indexes of 170 middle-aged and elderly people in Chengdu area. Fluorescence in situ hybridization (fish) was used to detect the total number of bacteria in their feces, Lactobacillus sp., Bacteroides sp., Clostridium sp.) Quantitative analysis was carried out. Results the concentration of Lactobacillus in 55 ~ 65 years old group was significantly higher than that in 55 years old group and under 55 years old group, the concentration of Bacteroides and Clostridium showed an age trend similar to that of Lactobacillus, and the correlation analysis showed that the age and the total number of bacteria were 0.054% P0.05, Lactobacillus quantity 0.150P0.05, Bacteroides sp. There was a positive correlation between the number of Rhizoma 0.190 (P0.05) and the number of Clostridium (0.180) (P0.05). The correlation coefficient between Lactobacillus and fasting blood glucose was 0.241 P0.01G, the ratio of Bacteroides / Clostridium was significantly positively correlated with HDL-C, and the total number of bacteria was positively correlated with IGG 0.177G. Conclusion the significant increase of intestinal Lactobacillus, Bacteroides and Clostridium may be one of the important characteristics of intestinal bacteria aging, and the number of intestinal Lactobacillus may be a new index for early detection of high risk population with diabetes mellitus. The development direction of probiotics in the middle-aged and aged population with the aim of improving Lactobacillus intestines needs further study.
【作者单位】：四川大学华西公共卫生学院;
【基金】：达能营养基金(No.4H0983)
【分类号】：R153.3

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