纳米二氧化硅对职业暴露人群健康危害的调查

发布时间：2018-07-05 05:35

本文选题：纳米二氧化硅 + 职业卫生调查　；参考：《东南大学学报(医学版)》2015年05期

【摘要】：目的:调查纳米二氧化硅(SiO2)对职业接触工人健康的影响。方法:采用职业卫生调查方法调查苏州某热塑材料混合公司和某橡胶有限公司的职业卫生现况;滤膜增重法测定总粉尘浓度(短时间接触浓度C-STEL,以其他粉尘计)。两个企业中接触纳米SiO2的工人与不接触纳米SiO2的技术管理人员分别设为接触组与对照组,各13例。测定血常规、生化指标,进行B超、心电图、肺功能、高千伏X线胸片,ELISA法测定血清中铜蓝蛋白(CP)、层粘连蛋白(LN)含量。结果:两个企业纳米SiO2投料口总粉尘浓度为0.26~255.5 mg·m-3;接触组工人中,除了分别有1名工人丙氨酸转氨酶(ALT)、尿素氮(BUN)、总胆红素(STB)分别超出正常水平外,其余各项指标均在正常参考值范围内,高千伏X线胸片、肺功能、心电图、B超检测均未发现异常;两组人员的血常规、血生化及CP、LN含量差异无统计学意义(P0.05)。结论:需加大样本量及随访研究纳米SiO2对接触人群健康的影响,加强纳米SiO2作业场所的职业卫生监督管理。
[Abstract]:Objective: to investigate the effect of nano silica (Sio 2) on the health of occupational workers. Methods: occupational hygiene survey method was used to investigate the occupational hygiene status of a thermoplastic material mixing company and a rubber limited company in Suzhou, and the total dust concentration (C-STELL) was determined by filtration membrane weight gain method (C-STELL). Workers exposed to nano-SiO _ 2 and technical managers who were not exposed to nano-SiO _ 2 in two enterprises were divided into exposure group and control group with 13 cases each. Blood routine, biochemical indexes, B ultrasound, electrocardiogram, lung function, high kilovolt chest radiograph Elisa method were used to determine serum levels of ceruloplasmin (CP) and laminin (LN). Results: the total dust concentration of nano-SiO _ 2 feeding port in two enterprises was 0.26 ~ 255.5 mg m ~ (-3). In the exposed group, except for one worker in the exposure group, alanine aminotransferase (alt), urea nitrogen (bun) and total bilirubin (STB) were above the normal level, respectively. The other indexes were within the normal reference value range, high kilovolt chest radiography, lung function, electrocardiogram, B-ultrasound detection were not abnormal; the two groups of blood routine, blood biochemical and CPLN content difference was not statistically significant (P0.05). Conclusion: it is necessary to increase the sample size and follow up to study the effect of nano-SiO _ 2 on the health of the exposed population and strengthen the occupational health supervision and management of nano-SiO _ 2 workplace.
【作者单位】：东南大学公共卫生学院环境医学工程教育部重点实验室;苏州工业园区疾病防治中心;
【基金】：国家自然科学基金面上项目(81273046) 江苏省预防医学科研项目(Y2012039)
【分类号】：R135

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