不同阶段母乳中唾液酸和铁水平分析

发布时间：2018-07-28 21:13

【摘要】：目的研究不同阶段母乳中唾液酸(sialic acid,SA)和铁的含量,为乳儿喂养和辅食添加及其神经发育评估提供科学依据。方法收集473份母乳(初乳191份,过渡乳115份,成熟乳109份和晚乳58份),母乳SA水平检测采用神经氨酸苷酶法,铁检测采用亚铁嗪法。组间SA水平比较采用方差分析,铁的比较采用非参数检验,相关性采用Pearson相关分析法。结果初乳SA平均浓度(1671.8±641.6)mg/L;过渡乳(1398.1±390.8)mg/L;成熟乳(419.5±292.0)mg/L,fi乳(262.8±80.9)mg/L,初乳SA水平显著高于过渡乳,过渡乳SA水平显著高于成熟乳,后者又显著高于fi乳(F=5.55,P=0.001)。初乳铁含量中位数0.07 mg/L,过渡乳0.09mg/L,成熟乳0.17 mg/L,fi乳0.21mg/L,初乳铁含量显著低于过渡乳(Z=2.61,P=0.009),过渡乳又显著低于成熟乳(Z=6.30,P0.001),后者又显著低于fi乳(Z=2.87,P=0.004)。母乳中SA含量与月龄负相关(r=-0.677,P0.001),铁含量与月龄正相关(r=0.333,P0.001)。结论母乳中SA浓度随着月龄的增加逐渐下降,而铁的含量随着日龄的增加逐渐增高。
[Abstract]:Objective to study the contents of sialic acid SA and iron in breast milk at different stages, and to provide scientific basis for infant feeding and supplementary food supplementation and their neurodevelopmental evaluation. Methods 473 human milk samples (191 colostrum, 115 transitional milk, 109 mature milk and 58 late milk) were collected. ANOVA was used to compare SA level among groups, non parametric test was used to compare iron, and Pearson correlation analysis was used to analyze correlation. Results the mean concentration of SA in colostrum was (1671.8 卤641.6) mg / L, that in transitional milk was (1398.1 卤390.8) mg / L, and that in mature milk was (419.5 卤292.0) mg / L, (262.8 卤80.9) mg / L, the SA level in colostrum was significantly higher than that in transitional milk, and the SA level in transitional milk was significantly higher than that in mature milk, which was significantly higher than that in fi milk. The median iron content was 0.07 mg / L in colostrum, 0.09 mg / L in transitional milk, 0.21 mg / L in mature milk 0.17 mg / L fi milk. The iron content in colostrum milk was significantly lower than that in transitional milk (Z _ (2.61) P ~ (+) _ (0.009), and that in transitional milk was significantly lower than that in mature milk (Z _ (6.30) P _ (0.001), and the latter was significantly lower than that in fi (Z _ (2.87) P _ (0.004). The content of SA in breast milk was negatively correlated with age (r = 0.677p 0.001), and the content of iron was positively correlated with age (r = 0.333P 0.001). Conclusion the concentration of SA in breast milk decreases gradually with the increase of age, while the content of iron increases with the increase of age.
【作者单位】：杭州师范大学附属医院;浙江大学医学院附属儿童医院;
【分类号】：R153.1

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