职业性慢性苯中毒患者微核检测结果分析

发布时间：2018-07-29 19:22

【摘要】：目的探讨职业性慢性苯中毒患者染色体损伤情况及其可能的影响因素。方法采用方便抽样法,以50例职业性慢性苯中毒患者为慢性苯中毒组,以53名无职业接触苯及其他有毒物质的工人为对照组。对研究对象进行问卷调查和血常规检测,采用胞质分裂阻滞微核法进行微核率检测。结果慢性苯中毒组患者周围血红细胞计数、血红蛋白水平、白细胞计数、血小板计数、淋巴细胞计数和中性粒细胞计数均低于对照组(P0.01),淋巴细胞微核率高于对照组(均值:6.26‰vs 3.91‰,P0.01),微核率偏高的比例高于对照组(46.0%vs 5.7%,P0.01);多因素Poisson回归分析结果显示,在排除性别、年龄、吸烟、饮酒和职业性苯接触工龄的影响后,脱离苯接触年限是慢性苯中毒组患者微核率的影响因素(P0.05)。结论职业性慢性苯中毒可导致患者淋巴细胞染色体损伤增加;脱离苯接触时间与染色体损伤呈正相关。
[Abstract]:Objective to investigate the chromosome damage and its possible influencing factors in occupational chronic benzene poisoning patients. Methods 50 patients with occupational chronic benzene poisoning and 53 workers without occupational exposure to benzene and other toxic substances were used as control group. The subjects were investigated by questionnaire and blood routine, and the micronucleus rate was detected by cytokinesis block micronucleus method. Results Peripheral blood red blood cell count, hemoglobin level, white blood cell count, platelet count in chronic benzene poisoning group, The lymphocyte count and neutrophil count were lower than that of the control group (P0.01), the micronucleus rate of lymphocytes was higher than that of the control group (mean: 6.26 鈥，

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