复方谷氨酰胺对重度放射性直肠炎的疗效及对炎性细胞因子水平的影响

发布时间：2017-12-27 00:03

  本文关键词：复方谷氨酰胺对重度放射性直肠炎的疗效及对炎性细胞因子水平的影响　出处：《临床消化病杂志》2016年01期 　论文类型：期刊论文

  更多相关文章： 放射性直肠炎 复方谷氨酰胺 肿瘤坏死因子-α 白细胞介素-

【摘要】：[目的]探讨复方谷氨酰胺对重度放射性直肠炎的治疗效果及对患者炎性细胞因子水平的影响。[方法]78例重度放射性直肠炎患者随机分为观察组(41例)和对照组(37例)。对照组采用5mg地塞米松加100mg利多卡因配100ml的0.9%氯化钠溶液每晚灌肠1次;观察组在对照组基础上加用复方谷氨酰胺口服,3次/d,每次3粒。治疗3周后评价2组疗效及血液中炎性细胞因子(TNF-α及IL-8)的变化。[结果]观察组临床有效率为78.0%(32/41),结肠镜检查缓解率为82.9%(34/41);对照组临床有效率为48.6%(18/37),结肠镜检查缓解率为56.8%(21/37);2组在临床有效率及结肠镜检查缓解率上比较均差异有统计学意义(P0.05)。治疗后2组血液中TNF-α及IL-8均下降,但观察组较对照组下降更明显(P0.05)。[结论]在用地塞米松加利多卡因灌肠治疗重度放射性直肠炎的基础上加用复方谷氨酰胺口服,可以显著提高临床有效率及结肠镜检查缓解率,并能显著降低血液中炎性细胞因子的水平。
[Abstract]:[Objective] to explore the therapeutic effect of Compound Glutamine on severe radiation proctitis and effects on cytokine levels in patients with osteoarthritis. Methods]78 cases of severe radiation proctitis patients were randomly divided into observation group (41 cases) and control group (37 cases). The control group was treated with 5mg dexamethasone plus 100mg lidocaine and 100ml 0.9% Sodium Chloride Solution for 1 times per night. The observation group was given compound glutamine orally, 3 times /d and 3 capsules each time on the basis of the control group. After 3 weeks of treatment, the effects of the 2 groups and the changes of inflammatory cytokines (TNF- alpha and IL-8) in the blood were evaluated. [results] the clinical effective rate of observation group was 78% (32/41), the remission rate of colonoscopy was 82.9% (34/41); the control group clinical effective rate was 48.6% (18/37), the remission rate of colonoscopy was 56.8% (21/37); the 2 groups in the clinical efficiency of colonoscopy and the remission rate is significantly difference between statistical significance (P0.05). After treatment, the blood TNF- alpha and IL-8 decreased in the 2 groups, but the decrease in the observation group was more obvious than that in the control group (P0.05). [Conclusion] in treatment with dexamethasone and lidocaine based enema in the treatment of radiation proctitis severe combined with compound glutamine orally, can the clinical efficiency of colonoscopy and the remission rate was significantly increased, and can decrease the inflammatory cytokine levels in the blood.
【作者单位】： 解放军309医院消化科;
【分类号】：R730.55
【正文快照】： 直肠癌、前列腺癌、宫颈癌、卵巢癌等盆腔内肿支持的腹泻或需卫生纸辅助才可排出的便血、腹胀瘤放射治疗后常见并发症为放射性直肠炎[1]。临床(X线平片证实肠管扩张);Ⅳ级:急性或亚急性肠梗主要表现为腹痛、腹泻、便血及里急后重,内镜下可阻,瘘管,穿孔和需输血的出血、需胃肠，

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