有氧运动对老年大鼠胃肠动力及血清中胃促生长素、瘦素水平的影响

发布时间：2018-01-01 07:36

本文关键词：有氧运动对老年大鼠胃肠动力及血清中胃促生长素、瘦素水平的影响　出处：《中国应用生理学杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的:探讨有氧运动对老年大鼠胃肠动力以及血清中胃促生长素(ghrelin)和瘦素(leptin)的影响。方法:雄性SD大鼠45只,分为青年对照组、老年对照组以及老年有氧运动组(n=15)。老年有氧运动组采用递增负荷的方式进行8周跑台运动。实验过程中连续观察并记录各组大鼠的摄食量、体重以及行为学特征;实验结束测定各组大鼠胃排空速率以及小肠推进比,血清Ghre-1in和Leptin。结果:与青年对照组相比,老年对照组大鼠摄食量、胃排空速率、小肠推进比、血清Ghrelin水平明显降低,体重、体脂和Leptin水平显著升高;与老年对照组相比,老年有氧运动组大鼠摄食量、胃排空速率、小肠推进比、血清Ghrelin水平明显升高,体重、体脂和Leptin水平明显降低。结论:有氧运动能促进老年大鼠食欲、提高胃肠动力、改善身体成分,其保护机制可能与血清中Ghrelin含量升高和Leptin含量降低有关。
[Abstract]:Objective: to investigate the effects of aerobic exercise on gastrointestinal motility and serum levels of ghrelin and leptin in aged rats. Methods: 45 male SD rats were enrolled in this study. Divided into youth control group. The aged control group and the old aerobic exercise group were treated with increasing load for 8 weeks. During the experiment, the feeding amount of the rats in each group was continuously observed and recorded. Weight and behavioral characteristics; At the end of the experiment, the gastric emptying rate, intestinal propulsion ratio, serum Ghre-1in and Leptin were measured. Results: compared with the young control group, the intake and gastric emptying rate of the aged rats in the control group were higher than those in the control group. Small intestinal propulsion ratio, serum Ghrelin level decreased significantly, body weight, body fat and Leptin levels increased significantly. Compared with the elderly control group, the elderly aerobic exercise group rats intake, gastric emptying rate, small intestinal propulsion ratio, serum Ghrelin level significantly increased, body weight. Conclusion: aerobic exercise can promote appetite, improve gastrointestinal motility and improve body composition in aged rats. The protective mechanism may be related to the increase of Ghrelin and the decrease of Leptin in serum.
【作者单位】：延安大学体育学院;
【分类号】：R87
【正文快照】： 功能性消化不良(functional dyspepsia,FD)是临床上比较常见的消化系统病症,尤其在老年人群中发病率较高,关于发病机制目前尚无定论[|]。老年人随年龄的增长消化不良酸病率明显增高。随着老龄化的推进和医学对健康理念的转变,如何改善老年人生活质量问櫝逐渐成为人们所关注的

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