多层螺旋CT评价他汀类药物对冠状动脉非钙化斑块的疗效

发布时间：2018-01-07 17:11

本文关键词：多层螺旋CT评价他汀类药物对冠状动脉非钙化斑块的疗效　出处：《中国医学影像学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的以多层螺旋CT评价他汀类药物治疗后,冠状动脉非钙化性斑块密度、体积及血管狭窄程度的变化,评估他汀类药物的疗效。资料与方法前瞻性研究80例多层螺旋CT检查发现的冠状动脉非钙化斑块患者,按低密度脂蛋白(LDL-C)水平、是否接受他汀类药物治疗分为治疗组和对照组,均于1年后CT复查主要斑块密度、体积和管腔狭窄程度及血脂变化。结果治疗组血清LDL-C治疗前(3.65±0.56)mmol/L、治疗1年后(2.32±0.24)mmol/L,三酰甘油(TG)治疗前(2.15±0.44)mmol/L、治疗1年后(1.86±0.31)mmol/L,治疗后两者水平下降,较治疗前差异有统计学意义(P0.05);治疗组高密度脂蛋白(HDL-C)治疗前(1.28±0.33)mmol/L、治疗1年后(1.31±0.41)mmol/L,治疗前后差异无统计学意义(P0.05)。对照组治疗1年后LDL-C水平下降,差异有统计学意义(P0.05),但HDL-C、TG水平变化差异无统计学意义(P0.05)。治疗组治疗1年后脂质斑块密度(51±12)HU,较治疗前升高,差异有统计学意义(P0.05),血管狭窄程度均较治疗前下降,差异均有统计学意义(P0.05)。治疗组纤维斑块密度和对照组脂质斑块、纤维斑块密度均无显著变化(P0.05);治疗组斑块体积由(87.3±19.2)mm~3下降至(75.6±14.2)mm~3,差异有统计学意义(P0.05),而斑块长度、厚度无显著变化(P0.05)。结论多层螺旋CT可量化评价冠状动脉非钙化斑块经他汀类药物治疗后的变化,他汀类药物能够有效调整血脂从而逆转或稳定冠状动脉非钙化斑块。
[Abstract]:Objective to evaluate the changes of coronary artery noncalcified plaque density volume and stenosis after statin treatment with multi-slice spiral CT. To evaluate the efficacy of statins. Materials and methods A prospective study was conducted in 80 patients with noncalcified plaque of coronary artery found by multi-slice spiral CT. Whether or not to receive statins was divided into two groups: treatment group and control group. The main plaque density was checked by CT after 1 year. Results Serum LDL-C was 3.65 卤0.56 mmol / L before treatment in the treatment group. One year after treatment, 2.32 卤0.24 mmol / L, triglyceride (TGG) was 2.15 卤0.44 mmol / L before treatment. After 1 year of treatment, the level of 1.86 卤0.31 mmol / L decreased after treatment, which was significantly higher than that before treatment (P 0.05). In the treatment group, high density lipoprotein (HDL-C) was 1.28 卤0.33 mmol / L before treatment, and 1.31 卤0.41 mmol / L after 1 year treatment. There was no significant difference before and after treatment (P 0.05). The level of LDL-C in the control group decreased after 1 year of treatment, the difference was statistically significant (P 0.05), but HDL-C. There was no significant difference in TG level. The density of lipid plaque in the treatment group was 51 卤12 HUU after 1 year treatment, which was higher than that before treatment, and the difference was statistically significant (P0.05). The degree of vascular stenosis was lower than that before treatment, and the difference was statistically significant (P 0.05). There was no significant change in the density of fibrous plaque in treatment group and lipid plaque in control group (P 0.05). In the treatment group, the volume of plaque decreased from 87.3 卤19.2mm3 to 75.6 卤14.2mm3, the difference was statistically significant (P 0.05), and the plaque length was significant. Conclusion Multi-slice spiral CT can quantitatively evaluate the changes of coronary artery non-calcified plaques after statin therapy. Statins can effectively regulate blood lipids to reverse or stabilize non-calcified plaque in the coronary artery.
【作者单位】：河南省许昌市中心医院放射科;复旦大学附属华东医院放射科;复旦大学附属华东医院心血管内科;
【分类号】：R541.4;R816.2
【正文快照】： 贾书杰1 JIA Shujie齐琳2 QI Lin史凯蕾3 SHI Kailei滑炎卿2 HUA Yanqing通讯作者滑炎卿Department of Radiology,Huadong HospitalAffiliated to Fudan University,Shanghai200040,ChinaAddress Correspondence to:HUA YanqingE-mail:Cjr.huayanqing@vip.163.comR541.4;R814.

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