浅析接受放疗的肺癌患者发生放射性肺炎的危险因素

发布时间：2018-01-21 08:34

本文关键词： 肺癌放疗放射性肺炎风险因素　出处：《当代医药论丛》2016年24期 　论文类型：期刊论文

【摘要】：目的 :探讨接受化疗的肺癌患者发生放射性肺炎的危险因素,以便为临床上预防放射性肺炎的工作提供参考。方法 :对在我院进行放疗的97例肺癌患者的临床资料进行回顾性研究。对这97例患者均进行放疗。在放疗结束后,对这97例患者均进行6~18个月的随访,统计其放射性肺炎的发生率。再按照是否发生放射性肺炎将这97例患者分为甲组和乙组。然后,对两组患者的年龄、性别、生活史、病灶的位置、肺癌的分期、肺病史、进行放疗的剂量、是否联合进行化疗、TNF-α(肿瘤坏死因子-α)的水平和IL-6(白细胞介素-6)的水平等临床资料进行单因素分析和Logistic多因素回归分析,从中找出接受放疗的肺癌患者发生放射性肺炎的危险因素。结果 :在这97例患者中,有26例患者发生了放射性肺炎,其放射性肺炎的发生率为26.8%。进行单因素分析的结果显示,两组患者的年龄、肺癌的分期、进行放疗的剂量、TNF-α的水平和HEIL-6的水平相比差异均具有统计学意义(P0.05)。进行多因素回归分析的结果显示,放疗的剂量50 Gy、患者TNF-α的水平24.5 ng·L-1是诱使肺癌患者发生放射性肺炎的主要危险因素,差异具有统计学意义(P0.05)。结论 :接受放疗的肺癌患者发生放射性肺炎与其放疗的使用剂量及其TNF-a的水平均密切相关。因此,在对肺癌患者进行放疗时,应对其TNF-α的水平进行监测,并控制其放疗的剂量,以降低其放射性肺炎的发生率,改善其放疗的预后。
[Abstract]:Objective: to investigate the risk factors of radiation pneumonia in lung cancer patients receiving chemotherapy. In order to provide a reference for clinical prevention of radiation pneumonia. Methods:. The clinical data of 97 patients with lung cancer undergoing radiotherapy in our hospital were retrospectively studied. All the 97 patients were followed up for 6 ~ 18 months to calculate the incidence of radiation pneumonia. According to the occurrence of radiation pneumonia, 97 patients were divided into two groups: group A and group B. Age, sex, life history, location of lesion, stage of lung cancer, history of lung disease, dose of radiotherapy, and combination chemotherapy were used in both groups. The clinical data of TNF- 伪 (tumor necrosis factor- 伪) and IL-6 (interleukin-6) were analyzed by univariate analysis and Logistic multivariate regression analysis. Risk factors for radiation pneumonia in lung cancer patients receiving radiotherapy were identified. Results: of the 97 patients, 26 had developed radiation pneumonia. The incidence of radiation pneumonia was 26.8. the results of univariate analysis showed that the age of the two groups, the stage of lung cancer, and the dose of radiotherapy. The level of TNF- 伪 was significantly different from that of HEIL-6 (P 0.05). The results of multivariate regression analysis showed that the dose of radiotherapy was 50 Gy. The level of TNF- 伪 in patients with lung cancer was 24.5 ng 路L ~ (-1), which was the main risk factor to induce radiation pneumonia in lung cancer patients. The difference was statistically significant (P 0.05). Conclusion: the incidence of radiation pneumonia in patients with lung cancer receiving radiotherapy is closely related to the dose of radiotherapy and the level of TNF-a. In order to reduce the incidence of radiation pneumonia and improve the prognosis of radiation therapy, the level of TNF- 伪 in patients with lung cancer should be monitored and the dose of radiotherapy should be controlled.
【作者单位】：徐州市沛县人民医院放疗科;徐州市中心医院康复科;
【分类号】：R734.2;R730.55
【正文快照】： 放射性肺炎是肺癌患者在进行放疗期间常见的并发症之一。此并发症会导致患者无法完成正常剂量的放疗,限制其治疗进程的推进,严重地影响其临床疗效及其生存质量[1]。因此,在对肺癌患者进行放疗前,明确诱使其发生放射性肺炎的危险因素,并为其采取积极的预防措施,对保证其放疗的

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