食管癌放疗过程中如何选择中药注射剂的网状Meta分析

发布时间：2018-01-23 21:45

本文关键词： 网状Meta分析食管癌中药注射剂放疗　出处：《中国中药杂志》2015年18期 　论文类型：期刊论文

【摘要】：采用网状Meta分析的方法间接比较中药注射剂联合放疗治疗食管癌的疗效和安全性。计算机检索Pub Med,the Cochrane Library,EMBASE,CBM,CNKI,万方和维普数据库,检索时间截止2014年9月,纳入中药注射剂联合放疗对比单纯放疗治疗食管癌的随机对照研究(RCT),2名研究者独立进行数据提取和质量评价,采用Ge MTC 0.14.3软件和Stata 12.0软件进行统计分析。最终纳入43个RCT,包含3 289例患者。纳入的各比较组构成星型网络,网状Meta分析结果提示7种中药注射剂在提高食管癌放疗患者的有效率和生活质量、降低呕心呕吐和白细胞减少发生率方面均显示出其优越性,然而7种中药注射剂之间比较差异并不显著。根据概率排序结果,参芪扶正和黄芪多糖注射剂在提高食管癌放疗患者有效率和生活质量上成为最有效注射剂的可能性最大,其次为华蟾素和康艾注射剂,然而由于参芪扶正和黄芪多糖受限于纳入研究数量和样本量,目前证据推荐在提高食管癌放疗患者有效率和生活质量上优先考虑华蟾素或康艾注射剂,而在降低放疗患者呕心呕吐(III-IV)和白细胞减少(III-IV)方面艾迪或复方苦参注射剂更具优势。今后研究重点关注参芪扶正和黄芪多糖等注射剂联合放疗治疗食管癌的疗效;并规范报告研究结果,尤其针对食管癌放疗相关的毒副作用。
[Abstract]:The efficacy and safety of traditional Chinese medicine injection combined with radiotherapy in the treatment of esophageal carcinoma were indirectly compared by reticular Meta analysis. Pub Med was searched by computer. The Cochrane Library EMBASEN CBMN CNKI, Wanfang and Weip databases, search time up to September 2014. A randomized controlled study of traditional Chinese medicine injection combined with radiotherapy and radiotherapy alone for esophageal cancer was conducted in two researchers to carry out data extraction and quality evaluation. GE MTC 0.14.3 software and Stata 12.0 software were used for statistical analysis. Finally 43 RCT were included. Three hundred and twenty-nine patients were included in the study. The results of reticular Meta analysis showed that the seven Chinese medicine injections could improve the effective rate and quality of life of patients with esophageal cancer radiotherapy. The lower incidence of nausea and vomiting and leukopenia showed its superiority, however, there was no significant difference among the seven Chinese medicine injections. Shenqi Fuzheng and Astragalus Polysaccharide injection in improving the effective rate and quality of life of patients with esophageal cancer radiotherapy is the most likely to become the most effective injection followed by cinobufacin and Kangai injection. However, because Shenqi Fuzheng and Astragalus polysaccharides are limited by the number of studies and sample size, it is recommended that cinobufacin or Kangai injection be given priority in improving the effective rate and quality of life of patients with esophageal cancer radiotherapy. In patients with radiotherapy, patients with nausea and vomiting (III-IVI) and leukopenia III-IVwere decreased. Aidi or compound Sophora flavescens injection have more advantages. In the future, we should focus on the therapeutic effect of Shenqi Fuzheng and Astragalus Polysaccharide combined with radiotherapy for esophageal carcinoma. The results of the study are reported in a standardized manner, especially for the side effects associated with radiotherapy for esophageal cancer.
【作者单位】：兰州大学第一临床医学院;兰州大学循证医学中心;兰州大学第二临床医学院;甘肃省循证医学与临床转化重点实验室;
【分类号】：R735.1;R730.55
【正文快照】： 食管癌是常见的消化道恶性肿瘤,全世界每年约有30万人死于食管癌。我国是世界上食管癌发病率和病死率最高的国家,每年发病率占全世界的50%,死亡率居世界首位。据全国防癌办公室第三次肿瘤普查资料显示,食管癌发病率居高不下的现状仍在持续,食管癌依然是危害我国人民生命和健康

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